Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker

Sanneke van Rooden; Maarten J Versluis; Michael K Liem; Julien Milles; Andrea B Maier; Ania M Oleksik; Andrew G Webb; Mark A van Buchem; Jeroen van der Grond

doi:10.1016/j.jalz.2013.02.002

Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker

Sanneke van Rooden, Maarten J Versluis, Michael K Liem, Julien Milles, Andrea B Maier, Ania M Oleksik, Andrew G Webb, Mark A van Buchem, Jeroen van der Grond

Neuromechanics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).

METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.

RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).

CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.

Original language	English
Pages (from-to)	e19-26
Journal	Alzheimers & Dementia
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/j.jalz.2013.02.002
Publication status	Published - Jan 2014

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Keywords

Aged
Aged, 80 and over
Alzheimer Disease/pathology
Cerebral Cortex/pathology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Statistics, Nonparametric

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker",

abstract = "BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.",

keywords = "Aged, Aged, 80 and over, Alzheimer Disease/pathology, Cerebral Cortex/pathology, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Statistics, Nonparametric",

author = "{van Rooden}, Sanneke and Versluis, {Maarten J} and Liem, {Michael K} and Julien Milles and Maier, {Andrea B} and Oleksik, {Ania M} and Webb, {Andrew G} and {van Buchem}, {Mark A} and {van der Grond}, Jeroen",

year = "2014",

month = jan,

doi = "10.1016/j.jalz.2013.02.002",

language = "English",

volume = "10",

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journal = "Alzheimers & Dementia",

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TY - JOUR

T1 - Cortical phase changes in Alzheimer's disease at 7T MRI

T2 - a novel imaging marker

AU - van Rooden, Sanneke

AU - Versluis, Maarten J

AU - Liem, Michael K

AU - Milles, Julien

AU - Maier, Andrea B

AU - Oleksik, Ania M

AU - Webb, Andrew G

AU - van Buchem, Mark A

AU - van der Grond, Jeroen

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.

AB - BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease/pathology

KW - Cerebral Cortex/pathology

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Statistics, Nonparametric

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DO - 10.1016/j.jalz.2013.02.002

M3 - Article

C2 - 23712002

SN - 1552-5260

VL - 10

SP - e19-26

JO - Alzheimers & Dementia

JF - Alzheimers & Dementia

IS - 1

ER -

Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker

Abstract

Bibliographical note

Keywords

UN SDGs

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