Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker

Sanneke van Rooden, Maarten J Versluis, Michael K Liem, Julien Milles, Andrea B Maier, Ania M Oleksik, Andrew G Webb, Mark A van Buchem, Jeroen van der Grond

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).

METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.

RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).

CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.

Original languageEnglish
Pages (from-to)e19-26
JournalAlzheimers & Dementia
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2014

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Alzheimer Disease
Magnetic Resonance Imaging
Amyloid
Parietal Lobe
Cerebral Cortex
Hippocampus
Magnetic Resonance Spectroscopy
Biomarkers
Pathology

Bibliographical note

Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Keywords

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease/pathology
  • Cerebral Cortex/pathology
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Statistics, Nonparametric

Cite this

van Rooden, S., Versluis, M. J., Liem, M. K., Milles, J., Maier, A. B., Oleksik, A. M., ... van der Grond, J. (2014). Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker. Alzheimers & Dementia, 10(1), e19-26. https://doi.org/10.1016/j.jalz.2013.02.002
van Rooden, Sanneke ; Versluis, Maarten J ; Liem, Michael K ; Milles, Julien ; Maier, Andrea B ; Oleksik, Ania M ; Webb, Andrew G ; van Buchem, Mark A ; van der Grond, Jeroen. / Cortical phase changes in Alzheimer's disease at 7T MRI : a novel imaging marker. In: Alzheimers & Dementia. 2014 ; Vol. 10, No. 1. pp. e19-26.
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abstract = "BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.",
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van Rooden, S, Versluis, MJ, Liem, MK, Milles, J, Maier, AB, Oleksik, AM, Webb, AG, van Buchem, MA & van der Grond, J 2014, 'Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker' Alzheimers & Dementia, vol. 10, no. 1, pp. e19-26. https://doi.org/10.1016/j.jalz.2013.02.002

Cortical phase changes in Alzheimer's disease at 7T MRI : a novel imaging marker. / van Rooden, Sanneke; Versluis, Maarten J; Liem, Michael K; Milles, Julien; Maier, Andrea B; Oleksik, Ania M; Webb, Andrew G; van Buchem, Mark A; van der Grond, Jeroen.

In: Alzheimers & Dementia, Vol. 10, No. 1, 01.2014, p. e19-26.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Cortical phase changes in Alzheimer's disease at 7T MRI

T2 - a novel imaging marker

AU - van Rooden, Sanneke

AU - Versluis, Maarten J

AU - Liem, Michael K

AU - Milles, Julien

AU - Maier, Andrea B

AU - Oleksik, Ania M

AU - Webb, Andrew G

AU - van Buchem, Mark A

AU - van der Grond, Jeroen

N1 - Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.

AB - BACKGROUND: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD).METHODS: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.RESULTS: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P < .005), and this was associated with individual Mini-Mental State Examination scores (r = -0.54, P < .05).CONCLUSION: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease/pathology

KW - Cerebral Cortex/pathology

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Statistics, Nonparametric

U2 - 10.1016/j.jalz.2013.02.002

DO - 10.1016/j.jalz.2013.02.002

M3 - Article

VL - 10

SP - e19-26

JO - Alzheimers & Dementia

JF - Alzheimers & Dementia

SN - 1552-5260

IS - 1

ER -