Corticotropin-releasing factor binding protein - A ligand trap?

O. Jahn, J. Radulovic, O. Stiedl, H. Tezval, K. Eckart, J. Spiess

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors. © 2005 Bentham Science Publishers Ltd.
Original languageEnglish
Pages (from-to)953-960
Number of pages8
JournalMini-Reviews in Medicinal Chemistry
Volume5
Issue number10
DOIs
Publication statusPublished - 2005

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