This paper provides an extensive overview of the literature on the coupling of column liquid chromatography (LC) and Fourier transform infrared spectrometry (FT-IR). Flow-cell-based FT-IR detection and early solvent- elimination interfaces for LC-FT-IR are discussed in brief. A comprehensive description is given of interface systems which use spraying to induce rapid eluent evaporation, and which essentially represent the state-of-the-art in LC-FT-IR. Fundamental aspects of FT-IR detection of deposited compounds are considered with special attention to the use of FT-IR microscopy. Finally, the interface systems suitable for reversed-phase LC are summarized and evaluated. The overview shows that solvent-elimination techniques can provide good sensitivity and enhanced spectral quality, and suggests that LC-FT-IR may well become a widely applicable technique for the unambiguous identification of trace-level sample constituents.