TY - JOUR
T1 - Craving on the move
T2 - targeting smoking memories with a novel 3MDR–smoking cessation protocol
AU - Koomen, Annel P.
AU - Kaag, Anne Marije
AU - Jongenelen, Kees A.M.
AU - Wouters, Rianne
AU - van Marle, Hein J.F.
AU - van den Heuvel, Odile A.
AU - van der Werf, Ysbrand D.
AU - De Vries, Taco J.
N1 - Publisher Copyright:
Copyright © 2024 Koomen, Kaag, Jongenelen, Wouters, van Marle, van den Heuvel, van der Werf and De Vries.
PY - 2024
Y1 - 2024
N2 - Introduction: Improved effectiveness and treatment adherence is needed in smoking cessation (SC) therapies. Another important challenge is to disrupt maladaptive drug-related memories. To achieve these goals, we developed a novel treatment strategy on the basis of motion-assisted memory desensitization and reprocessing (3MDR). Methods: In this study, the added effect of a distractor task following memory recall during a newly designed 3-day SC version of 3MDR (3MDR-SC) protocol on reducing smoking cue–elicited craving was investigated in abstinent chronic smokers. Chronic smokers were randomly allocated to an active 3MDR-SC group (receiving 3MDR-SC with a working memory distractor task) (n = 42) or a control 3MDR-SC group (receiving 3MDR-SC with a non-distracting task) (n = 39). Smoking cue–induced craving and physiological measures were assessed at baseline (T0) and 1 day after the intervention (T4), and smoking behavior was measured at T0 and 2-week (FU1) and 3-month (FU2) follow-up. Results: Significant decreases in cue-induced craving from T0 to T4 and daily cigarette use from T0 to FU1 and FU2 were observed but not differ between the two experimental groups. Cue-induced changes in heart-rate variability and skin conductance, which did not differ from T0 to T4, and relapse at FU2 were also not different between groups. Dropout rate during intervention was 2.5%. Conclusions: The 3-day 3MDR-SC intervention resulted in a reduction in cue-induced craving and smoking behavior and showed very good treatment adherence. There was no added effect of the distractor task on 3MDR-SC efficacy. Further studies, including a treatment as usual control, are needed to confirm 3MDR-SC as an effective SC therapy.
AB - Introduction: Improved effectiveness and treatment adherence is needed in smoking cessation (SC) therapies. Another important challenge is to disrupt maladaptive drug-related memories. To achieve these goals, we developed a novel treatment strategy on the basis of motion-assisted memory desensitization and reprocessing (3MDR). Methods: In this study, the added effect of a distractor task following memory recall during a newly designed 3-day SC version of 3MDR (3MDR-SC) protocol on reducing smoking cue–elicited craving was investigated in abstinent chronic smokers. Chronic smokers were randomly allocated to an active 3MDR-SC group (receiving 3MDR-SC with a working memory distractor task) (n = 42) or a control 3MDR-SC group (receiving 3MDR-SC with a non-distracting task) (n = 39). Smoking cue–induced craving and physiological measures were assessed at baseline (T0) and 1 day after the intervention (T4), and smoking behavior was measured at T0 and 2-week (FU1) and 3-month (FU2) follow-up. Results: Significant decreases in cue-induced craving from T0 to T4 and daily cigarette use from T0 to FU1 and FU2 were observed but not differ between the two experimental groups. Cue-induced changes in heart-rate variability and skin conductance, which did not differ from T0 to T4, and relapse at FU2 were also not different between groups. Dropout rate during intervention was 2.5%. Conclusions: The 3-day 3MDR-SC intervention resulted in a reduction in cue-induced craving and smoking behavior and showed very good treatment adherence. There was no added effect of the distractor task on 3MDR-SC efficacy. Further studies, including a treatment as usual control, are needed to confirm 3MDR-SC as an effective SC therapy.
KW - craving
KW - cue exposure
KW - EMDR
KW - memory reconsolidation
KW - smoking
KW - smoking cessation
KW - tobacco use disorder
KW - working memory
UR - http://www.scopus.com/inward/record.url?scp=85212876734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85212876734&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2024.1398027
DO - 10.3389/fpsyt.2024.1398027
M3 - Article
AN - SCOPUS:85212876734
SN - 1664-0640
VL - 15
SP - 1
EP - 10
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
M1 - 1398027
ER -