Critical Involvement of Macrophage Infiltration in the Development of Sjogren's Syndrome-Associated Dry Eye

D. Zhou, Y.T. Chen, F.L. Chen, M. Gallup, T. Vijmasi, A.F. Bahrami, L.B. Noble, N. van Rooijen, N.A. McNamara

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Abstract

Lymphocytic infiltration of the lacrimal gland and ocular surface in autoimmune diseases such as Sjögren's syndrome (SS) causes an aqueous-deficient dry eye that is associated with significant morbidity. Previous studies from our laboratory and others have established autoimmune regulator (Aire)deficient mice as a useful model to examine exocrinopathy and ocular surface disease associated with SS. Consistent with human SS, autoreactive CD4
Original languageEnglish
Pages (from-to)753-760
JournalThe American Journal of Pathology
Volume181
Issue number3
DOIs
Publication statusPublished - 2012

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