Critical Involvement of Macrophage Infiltration in the Development of Sjogren's Syndrome-Associated Dry Eye

D. Zhou; Y.T. Chen; F.L. Chen; M. Gallup; T. Vijmasi; A.F. Bahrami; L.B. Noble; N. van Rooijen; N.A. McNamara

doi:10.1016/j.ajpath.2012.05.014

Critical Involvement of Macrophage Infiltration in the Development of Sjogren's Syndrome-Associated Dry Eye

D. Zhou, Y.T. Chen, F.L. Chen, M. Gallup, T. Vijmasi, A.F. Bahrami, L.B. Noble, N. van Rooijen, N.A. McNamara

Social and Cultural Anthropology

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Abstract

Lymphocytic infiltration of the lacrimal gland and ocular surface in autoimmune diseases such as Sjögren's syndrome (SS) causes an aqueous-deficient dry eye that is associated with significant morbidity. Previous studies from our laboratory and others have established autoimmune regulator (Aire)deficient mice as a useful model to examine exocrinopathy and ocular surface disease associated with SS. Consistent with human SS, autoreactive CD4

Original language	English
Pages (from-to)	753-760
Journal	The American Journal of Pathology
Volume	181
Issue number	3
DOIs	https://doi.org/10.1016/j.ajpath.2012.05.014
Publication status	Published - 2012

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10.1016/j.ajpath.2012.05.014

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AU - Zhou, D.

AU - Chen, Y.T.

AU - Chen, F.L.

AU - Gallup, M.

AU - Vijmasi, T.

AU - Bahrami, A.F.

AU - Noble, L.B.

AU - van Rooijen, N.

AU - McNamara, N.A.

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AB - Lymphocytic infiltration of the lacrimal gland and ocular surface in autoimmune diseases such as Sjögren's syndrome (SS) causes an aqueous-deficient dry eye that is associated with significant morbidity. Previous studies from our laboratory and others have established autoimmune regulator (Aire)deficient mice as a useful model to examine exocrinopathy and ocular surface disease associated with SS. Consistent with human SS, autoreactive CD4

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JF - The American Journal of Pathology

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Critical Involvement of Macrophage Infiltration in the Development of Sjogren's Syndrome-Associated Dry Eye

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