Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta-analysis

Eline van der Valk; Ozair Abawi; Mostafa Mohseni; Amir Abdelmoumen; Vincent Wester; Bibian van der Voorn; Anand Iyer; Erica van den Akker; Sanne Hoeks; Sjoerd van den Berg; Yolanda de Rijke; Tobias Stalder; Elisabeth van Rossum

doi:10.1111/obr.13376

Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta-analysis

Eline van der Valk, Ozair Abawi, Mostafa Mohseni, Amir Abdelmoumen, Vincent Wester, Bibian van der Voorn, Anand Iyer, Erica van den Akker, Sanne Hoeks, Sjoerd van den Berg, Yolanda de Rijke, Tobias Stalder, Elisabeth van Rossum

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

BACKGROUND: Long-term glucocorticoids (HairGC) measured in scalp hair have been associated with body mass index (BMI), waist circumference (WC), and waist-hip-ratio (WHR) in several cross-sectional studies. We aimed to investigate the magnitude, strength, and clinical relevance of these relations across all ages.

METHODS: We performed a systematic review and meta-analysis (PROSPERO registration CRD42020205187) searching for articles relating HairGC to measures of obesity. Main outcomes were bivariate correlation coefficients and unadjusted simple linear regression coefficients relating hair cortisol (HairF) and hair cortisone (HairE) to BMI, WC, and WHR.

RESULTS: We included k = 146 cohorts (n = 34,342 individuals). HairGC were positively related to all anthropometric measurements. The strongest correlation and largest effect size were seen for HairE-WC: pooled correlation 0.18 (95%CI 0.11-0.24; k = 7; n = 3,158; I2 = 45.7%) and pooled regression coefficient 11.0 cm increase in WC per point increase in 10-log-transformed HairE (pg/mg) on liquid-chromatography-(tandem) mass spectrometry (LC-MS) (95%CI 10.1-11.9 cm; k = 6; n = 3,102). Pooled correlation for HairF-BMI was 0.10 (95%CI 0.08-0.13; k = 122; n = 26,527; I2 = 51.2%) and pooled regression coefficient 0.049 kg/m2 per point increase in 10-log-transformed HairF (pg/mg) on LC-MS (95%CI 0.045-0.054 kg/m2 ; k = 26; n = 11,635).

DISCUSSION: There is a consistent positive association between HairGC and BMI, WC, and WHR, most prominently and clinically relevant for HairE-WC. These findings overall suggest an altered setpoint of the hypothalamic-pituitary-adrenal axis with increasing central adiposity.

Original language	English
Article number	e13376
Pages (from-to)	1-21
Number of pages	21
Journal	Obesity reviews
Volume	23
Issue number	3
Early online date	22 Nov 2021
DOIs	https://doi.org/10.1111/obr.13376
Publication status	Published - Mar 2022

Bibliographical note

Funding

The authors wish to thank Wichor Bramer, Maarten Engel, and Sabrina Gunput from the Erasmus MC Medical Library for developing and updating the search strategies. We also wish to thank all authors that were contacted who provided us with additional information. OA, BvdV, EvdA, and EvR are supported by the Elisabeth Foundation, a nonprofit organization supporting academic obesity research. EvR is supported by the Netherlands Organization of Scientific Research NWO, ZonMW Vidi Grant/Award Number: 91716453.

Funders	Funder number
Elisabeth Foundation
Erasmus MC Medical Library
Netherlands Organization of Scientific Research NWO
ZonMw	91716453

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van der Valk, E., Abawi, O., Mohseni, M., Abdelmoumen, A., Wester, V., van der Voorn, B., Iyer, A., van den Akker, E., Hoeks, S., van den Berg, S., de Rijke, Y., Stalder, T., & van Rossum, E. (2022). Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta-analysis. Obesity reviews, 23(3), 1-21. Article e13376. https://doi.org/10.1111/obr.13376

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title = "Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta-analysis",

abstract = "BACKGROUND: Long-term glucocorticoids (HairGC) measured in scalp hair have been associated with body mass index (BMI), waist circumference (WC), and waist-hip-ratio (WHR) in several cross-sectional studies. We aimed to investigate the magnitude, strength, and clinical relevance of these relations across all ages.METHODS: We performed a systematic review and meta-analysis (PROSPERO registration CRD42020205187) searching for articles relating HairGC to measures of obesity. Main outcomes were bivariate correlation coefficients and unadjusted simple linear regression coefficients relating hair cortisol (HairF) and hair cortisone (HairE) to BMI, WC, and WHR.RESULTS: We included k = 146 cohorts (n = 34,342 individuals). HairGC were positively related to all anthropometric measurements. The strongest correlation and largest effect size were seen for HairE-WC: pooled correlation 0.18 (95%CI 0.11-0.24; k = 7; n = 3,158; I2 = 45.7%) and pooled regression coefficient 11.0 cm increase in WC per point increase in 10-log-transformed HairE (pg/mg) on liquid-chromatography-(tandem) mass spectrometry (LC-MS) (95%CI 10.1-11.9 cm; k = 6; n = 3,102). Pooled correlation for HairF-BMI was 0.10 (95%CI 0.08-0.13; k = 122; n = 26,527; I2 = 51.2%) and pooled regression coefficient 0.049 kg/m2 per point increase in 10-log-transformed HairF (pg/mg) on LC-MS (95%CI 0.045-0.054 kg/m2 ; k = 26; n = 11,635).DISCUSSION: There is a consistent positive association between HairGC and BMI, WC, and WHR, most prominently and clinically relevant for HairE-WC. These findings overall suggest an altered setpoint of the hypothalamic-pituitary-adrenal axis with increasing central adiposity.",

author = "{van der Valk}, Eline and Ozair Abawi and Mostafa Mohseni and Amir Abdelmoumen and Vincent Wester and {van der Voorn}, Bibian and Anand Iyer and {van den Akker}, Erica and Sanne Hoeks and {van den Berg}, Sjoerd and {de Rijke}, Yolanda and Tobias Stalder and {van Rossum}, Elisabeth",

note = "{\textcopyright} 2021 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.",

year = "2022",

month = mar,

doi = "10.1111/obr.13376",

language = "English",

volume = "23",

pages = "1--21",

journal = "Obesity reviews",

issn = "1467-7881",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

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van der Valk, E, Abawi, O, Mohseni, M, Abdelmoumen, A, Wester, V, van der Voorn, B, Iyer, A, van den Akker, E, Hoeks, S, van den Berg, S, de Rijke, Y, Stalder, T & van Rossum, E 2022, 'Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta-analysis', Obesity reviews, vol. 23, no. 3, e13376, pp. 1-21. https://doi.org/10.1111/obr.13376

Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta-analysis. / van der Valk, Eline; Abawi, Ozair; Mohseni, Mostafa et al.
In: Obesity reviews, Vol. 23, No. 3, e13376, 03.2022, p. 1-21.

Research output: Contribution to Journal › Review article › Academic › peer-review

TY - JOUR

T1 - Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants

T2 - A systematic review and meta-analysis

AU - van der Valk, Eline

AU - Abawi, Ozair

AU - Mohseni, Mostafa

AU - Abdelmoumen, Amir

AU - Wester, Vincent

AU - van der Voorn, Bibian

AU - Iyer, Anand

AU - van den Akker, Erica

AU - Hoeks, Sanne

AU - van den Berg, Sjoerd

AU - de Rijke, Yolanda

AU - Stalder, Tobias

AU - van Rossum, Elisabeth

PY - 2022/3

Y1 - 2022/3

N2 - BACKGROUND: Long-term glucocorticoids (HairGC) measured in scalp hair have been associated with body mass index (BMI), waist circumference (WC), and waist-hip-ratio (WHR) in several cross-sectional studies. We aimed to investigate the magnitude, strength, and clinical relevance of these relations across all ages.METHODS: We performed a systematic review and meta-analysis (PROSPERO registration CRD42020205187) searching for articles relating HairGC to measures of obesity. Main outcomes were bivariate correlation coefficients and unadjusted simple linear regression coefficients relating hair cortisol (HairF) and hair cortisone (HairE) to BMI, WC, and WHR.RESULTS: We included k = 146 cohorts (n = 34,342 individuals). HairGC were positively related to all anthropometric measurements. The strongest correlation and largest effect size were seen for HairE-WC: pooled correlation 0.18 (95%CI 0.11-0.24; k = 7; n = 3,158; I2 = 45.7%) and pooled regression coefficient 11.0 cm increase in WC per point increase in 10-log-transformed HairE (pg/mg) on liquid-chromatography-(tandem) mass spectrometry (LC-MS) (95%CI 10.1-11.9 cm; k = 6; n = 3,102). Pooled correlation for HairF-BMI was 0.10 (95%CI 0.08-0.13; k = 122; n = 26,527; I2 = 51.2%) and pooled regression coefficient 0.049 kg/m2 per point increase in 10-log-transformed HairF (pg/mg) on LC-MS (95%CI 0.045-0.054 kg/m2 ; k = 26; n = 11,635).DISCUSSION: There is a consistent positive association between HairGC and BMI, WC, and WHR, most prominently and clinically relevant for HairE-WC. These findings overall suggest an altered setpoint of the hypothalamic-pituitary-adrenal axis with increasing central adiposity.

AB - BACKGROUND: Long-term glucocorticoids (HairGC) measured in scalp hair have been associated with body mass index (BMI), waist circumference (WC), and waist-hip-ratio (WHR) in several cross-sectional studies. We aimed to investigate the magnitude, strength, and clinical relevance of these relations across all ages.METHODS: We performed a systematic review and meta-analysis (PROSPERO registration CRD42020205187) searching for articles relating HairGC to measures of obesity. Main outcomes were bivariate correlation coefficients and unadjusted simple linear regression coefficients relating hair cortisol (HairF) and hair cortisone (HairE) to BMI, WC, and WHR.RESULTS: We included k = 146 cohorts (n = 34,342 individuals). HairGC were positively related to all anthropometric measurements. The strongest correlation and largest effect size were seen for HairE-WC: pooled correlation 0.18 (95%CI 0.11-0.24; k = 7; n = 3,158; I2 = 45.7%) and pooled regression coefficient 11.0 cm increase in WC per point increase in 10-log-transformed HairE (pg/mg) on liquid-chromatography-(tandem) mass spectrometry (LC-MS) (95%CI 10.1-11.9 cm; k = 6; n = 3,102). Pooled correlation for HairF-BMI was 0.10 (95%CI 0.08-0.13; k = 122; n = 26,527; I2 = 51.2%) and pooled regression coefficient 0.049 kg/m2 per point increase in 10-log-transformed HairF (pg/mg) on LC-MS (95%CI 0.045-0.054 kg/m2 ; k = 26; n = 11,635).DISCUSSION: There is a consistent positive association between HairGC and BMI, WC, and WHR, most prominently and clinically relevant for HairE-WC. These findings overall suggest an altered setpoint of the hypothalamic-pituitary-adrenal axis with increasing central adiposity.

U2 - 10.1111/obr.13376

DO - 10.1111/obr.13376

M3 - Review article

C2 - 34811866

SN - 1467-7881

VL - 23

SP - 1

EP - 21

JO - Obesity reviews

JF - Obesity reviews

IS - 3

M1 - e13376

ER -

Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta-analysis

Abstract

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