Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome.

R. Singh, C. Kraft, R. Jaiswal, K. Sejwal, V.B. Kasaragod, J. Kuper, J. Berger, T. Mielke, J. Luirink, S. Bhushan

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: SecA targets preproteins to the protein-conducting channel in bacteria. Results: Both the single and double copies of SecA bind to the 70S ribosome. Conclusion: Two copies of SecA completely surround the polypeptide tunnel exit. Significance: The structures suggest a function of the dimeric form of SecA on the ribosome. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
LanguageEnglish
JournalJournal of Biological Chemistry
DOIs
Publication statusPublished - 2014

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Ribosomes
Bacteria
Tunnels
Electrons
Peptides
Proteins

Bibliographical note

1083-351x Singh, Rajkumar Kraft, Christian Jaiswal, Rahul Sejwal, Kushal Kasaragod, Vikram Babu Kuper, Jochen Berger, Jorg Mielke, Thorsten Luirink, Joen Bhushan, Shashi Journal article J Biol Chem. 2014 Jan 17.

Cite this

Singh, R., Kraft, C., Jaiswal, R., Sejwal, K., Kasaragod, V. B., Kuper, J., ... Bhushan, S. (2014). Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M113.506634
Singh, R. ; Kraft, C. ; Jaiswal, R. ; Sejwal, K. ; Kasaragod, V.B. ; Kuper, J. ; Berger, J. ; Mielke, T. ; Luirink, J. ; Bhushan, S. / Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome. In: Journal of Biological Chemistry. 2014.
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abstract = "Background: SecA targets preproteins to the protein-conducting channel in bacteria. Results: Both the single and double copies of SecA bind to the 70S ribosome. Conclusion: Two copies of SecA completely surround the polypeptide tunnel exit. Significance: The structures suggest a function of the dimeric form of SecA on the ribosome. {\circledC} 2014 by The American Society for Biochemistry and Molecular Biology, Inc.",
author = "R. Singh and C. Kraft and R. Jaiswal and K. Sejwal and V.B. Kasaragod and J. Kuper and J. Berger and T. Mielke and J. Luirink and S. Bhushan",
note = "1083-351x Singh, Rajkumar Kraft, Christian Jaiswal, Rahul Sejwal, Kushal Kasaragod, Vikram Babu Kuper, Jochen Berger, Jorg Mielke, Thorsten Luirink, Joen Bhushan, Shashi Journal article J Biol Chem. 2014 Jan 17.",
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Singh, R, Kraft, C, Jaiswal, R, Sejwal, K, Kasaragod, VB, Kuper, J, Berger, J, Mielke, T, Luirink, J & Bhushan, S 2014, 'Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome.', Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M113.506634

Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome. / Singh, R.; Kraft, C.; Jaiswal, R.; Sejwal, K.; Kasaragod, V.B.; Kuper, J.; Berger, J.; Mielke, T.; Luirink, J.; Bhushan, S.

In: Journal of Biological Chemistry, 2014.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome.

AU - Singh, R.

AU - Kraft, C.

AU - Jaiswal, R.

AU - Sejwal, K.

AU - Kasaragod, V.B.

AU - Kuper, J.

AU - Berger, J.

AU - Mielke, T.

AU - Luirink, J.

AU - Bhushan, S.

N1 - 1083-351x Singh, Rajkumar Kraft, Christian Jaiswal, Rahul Sejwal, Kushal Kasaragod, Vikram Babu Kuper, Jochen Berger, Jorg Mielke, Thorsten Luirink, Joen Bhushan, Shashi Journal article J Biol Chem. 2014 Jan 17.

PY - 2014

Y1 - 2014

N2 - Background: SecA targets preproteins to the protein-conducting channel in bacteria. Results: Both the single and double copies of SecA bind to the 70S ribosome. Conclusion: Two copies of SecA completely surround the polypeptide tunnel exit. Significance: The structures suggest a function of the dimeric form of SecA on the ribosome. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

AB - Background: SecA targets preproteins to the protein-conducting channel in bacteria. Results: Both the single and double copies of SecA bind to the 70S ribosome. Conclusion: Two copies of SecA completely surround the polypeptide tunnel exit. Significance: The structures suggest a function of the dimeric form of SecA on the ribosome. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

U2 - 10.1074/jbc.M113.506634

DO - 10.1074/jbc.M113.506634

M3 - Article

JO - Journal of Biological Chemistry

T2 - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

ER -