Abstract
Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and receptors. The subgroup α-Ctx specifically and selectively binds to subtypes of nicotinic acetylcholine receptors (nAChRs), which are targets for treatment of several neurological disorders. Here we present the structure at a resolution of 2.4 Å of α-Ctx PnIA (A10L D14K), a potent blocker of the α
Original language | English |
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Pages (from-to) | 582-588 |
Number of pages | 7 |
Journal | Nature Structural and Molecular Biology |
Volume | 12 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2005 |