Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant

P.H.N. Celie, I.E. Kasheverov, D.Y. Mordventisev, R.C. Hogg, P. van Nierop, R. van Elk, S.E. van Rossum-Fikkert, M.N. Zhmak, D. Bertrand, V. Tsetlin, T.K. Sixma, A.B. Smit

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and receptors. The subgroup α-Ctx specifically and selectively binds to subtypes of nicotinic acetylcholine receptors (nAChRs), which are targets for treatment of several neurological disorders. Here we present the structure at a resolution of 2.4 Å of α-Ctx PnIA (A10L D14K), a potent blocker of the α
Original languageEnglish
Pages (from-to)582-588
Number of pages7
JournalNature Structural and Molecular Biology
Volume12
Issue number7
DOIs
Publication statusPublished - 2005

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