TY - JOUR
T1 - Crystallographic analysis of tricolosan bound to enoyl reductase.
AU - Roujeinikova, A.
AU - Levy, C.W.
AU - Rowsell, S.
AU - Sedelnikova, S.
AU - Baker, P.J.
AU - Minshull, C.A.
AU - Mistry, A.
AU - Colls, J.G.
AU - Camble, R.
AU - Stuitje, A.R.
AU - Slabas, A.R.
AU - Rafferty, J.B.
AU - Pauptit, R.A.
AU - Viner, A
AU - Rice, D.W.
PY - 1999
Y1 - 1999
N2 - Molecular genetic studies with strains of Escherichia coli resistant to triclosan, an ingredient of many anti-bacterial household goods, have suggested that this compound works by acting as an inhibitor of enoyl reductase (ENR) and thereby blocking lipid biosynthesis. We present structural analyses correlated with inhibition data, on the complexes of E. coli and Brassica napus ENR with triclosan and NAD
AB - Molecular genetic studies with strains of Escherichia coli resistant to triclosan, an ingredient of many anti-bacterial household goods, have suggested that this compound works by acting as an inhibitor of enoyl reductase (ENR) and thereby blocking lipid biosynthesis. We present structural analyses correlated with inhibition data, on the complexes of E. coli and Brassica napus ENR with triclosan and NAD
UR - https://www.scopus.com/pages/publications/0033607650
UR - https://www.scopus.com/inward/citedby.url?scp=0033607650&partnerID=8YFLogxK
U2 - 10.1006/jmbi.1999.3240
DO - 10.1006/jmbi.1999.3240
M3 - Article
SN - 0022-2836
VL - 294
SP - 527
EP - 535
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
ER -