Cultured rat striatal and cortcal astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development.

C.H. Langeveld, E. Schepens, C.A.M. Jongenelen, J.C. Stoof, A. Bast, B. Drukarch

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Reactive oxygen species (ROS), including hydrogen peroxide, are supposed to be involved in the degeneration of dopaminergic neurons in Parkinson's disease. The potential role of astrocytes against neurotoxic effects of ROS was studied in cocultures of rat mesencephalic neurons and rat striatal or cortical astrocytes. Neuronal [
Original languageEnglish
Pages (from-to)13-16
JournalNeuroscience Letters
Volume192
DOIs
Publication statusPublished - 1995

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