Current topics in signal transduction in bacteria

K J Hellingwerf, W C Crielaard, M Joost Teixeira de Mattos, W.D. Hoff, R Kort, D T Verhamme, C Avignone-Rossa

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Among the signal transfer systems in bacteria two types predominate: two-component regulatory systems and quorum sensing systems. Both types of system can mediate signal transfer across the bacterial cell envelope; however, the signalling molecule typically is not taken up into the cells in the former type of system, whereas it usually is in the latter. The Two-component systems include the recently described (eukaryotic) phosphorelay systems; quorum sensing systems can be based upon autoinducers of the N-acylated homoserine lactones, and on autoinducers of a peptidic nature. A single bacterial cell contains many signalling modules that primarily operate in parallel. This may give rise to neural-network behaviour. Recently, however, for both types of basic signal transfer modules, it has been demonstrated that they also can be organised in series (i.e. in a hierarchical order). Besides their hierarchical position in the signal transduction network of the cell, the spatial distribution of individual signalling modules may also be an important factor in their efficiency in signal transfer. Many challenges lie hidden in future work to understand these signal transfer processes in more detail. These are discussed here, with emphasis on the mutual interactions between different signal transfer processes. Successful contributions to this work will require rigorous mathematical modelling of the performance of signal transduction components, and -networks, as well as studies on light-sensing signal transduction systems, because of the unsurpassed time resolution obtainable in those latter systems, the opportunity to apply repeated reproducible stimuli, etc. The increased understanding of bacterial behaviour that already has resulted--and may further result--from these studies, can be used to fine-tune the beneficial activities of bacteria and/or more efficiently inhibit their deleterious ones.

Original languageEnglish
Pages (from-to)211-27
Number of pages17
JournalAntonie van Leeuwenhoek
Volume74
Issue number4
DOIs
Publication statusPublished - Nov 1998

Fingerprint

Signal Transduction
Bacteria
Quorum Sensing
Acyl-Butyrolactones
Light Signal Transduction

Keywords

  • Bacteria
  • Homoserine
  • Peptides
  • Pheromones
  • Receptors, Cell Surface
  • Signal Transduction
  • Journal Article
  • Review

Cite this

Hellingwerf, K. J., Crielaard, W. C., Joost Teixeira de Mattos, M., Hoff, W. D., Kort, R., Verhamme, D. T., & Avignone-Rossa, C. (1998). Current topics in signal transduction in bacteria. Antonie van Leeuwenhoek, 74(4), 211-27. https://doi.org/10.1023/A:1001738419877
Hellingwerf, K J ; Crielaard, W C ; Joost Teixeira de Mattos, M ; Hoff, W.D. ; Kort, R ; Verhamme, D T ; Avignone-Rossa, C. / Current topics in signal transduction in bacteria. In: Antonie van Leeuwenhoek. 1998 ; Vol. 74, No. 4. pp. 211-27.
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Hellingwerf, KJ, Crielaard, WC, Joost Teixeira de Mattos, M, Hoff, WD, Kort, R, Verhamme, DT & Avignone-Rossa, C 1998, 'Current topics in signal transduction in bacteria' Antonie van Leeuwenhoek, vol. 74, no. 4, pp. 211-27. https://doi.org/10.1023/A:1001738419877

Current topics in signal transduction in bacteria. / Hellingwerf, K J; Crielaard, W C; Joost Teixeira de Mattos, M; Hoff, W.D.; Kort, R; Verhamme, D T; Avignone-Rossa, C.

In: Antonie van Leeuwenhoek, Vol. 74, No. 4, 11.1998, p. 211-27.

Research output: Contribution to JournalReview articleAcademicpeer-review

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AU - Hellingwerf, K J

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AB - Among the signal transfer systems in bacteria two types predominate: two-component regulatory systems and quorum sensing systems. Both types of system can mediate signal transfer across the bacterial cell envelope; however, the signalling molecule typically is not taken up into the cells in the former type of system, whereas it usually is in the latter. The Two-component systems include the recently described (eukaryotic) phosphorelay systems; quorum sensing systems can be based upon autoinducers of the N-acylated homoserine lactones, and on autoinducers of a peptidic nature. A single bacterial cell contains many signalling modules that primarily operate in parallel. This may give rise to neural-network behaviour. Recently, however, for both types of basic signal transfer modules, it has been demonstrated that they also can be organised in series (i.e. in a hierarchical order). Besides their hierarchical position in the signal transduction network of the cell, the spatial distribution of individual signalling modules may also be an important factor in their efficiency in signal transfer. Many challenges lie hidden in future work to understand these signal transfer processes in more detail. These are discussed here, with emphasis on the mutual interactions between different signal transfer processes. Successful contributions to this work will require rigorous mathematical modelling of the performance of signal transduction components, and -networks, as well as studies on light-sensing signal transduction systems, because of the unsurpassed time resolution obtainable in those latter systems, the opportunity to apply repeated reproducible stimuli, etc. The increased understanding of bacterial behaviour that already has resulted--and may further result--from these studies, can be used to fine-tune the beneficial activities of bacteria and/or more efficiently inhibit their deleterious ones.

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KW - Receptors, Cell Surface

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Hellingwerf KJ, Crielaard WC, Joost Teixeira de Mattos M, Hoff WD, Kort R, Verhamme DT et al. Current topics in signal transduction in bacteria. Antonie van Leeuwenhoek. 1998 Nov;74(4):211-27. https://doi.org/10.1023/A:1001738419877