Cytochrome bd in Mycobacterium tuberculosis: A respiratory chain protein involved in the defense against antibacterials

Ludovica Mascolo; Dirk Bald

doi:10.1016/j.pbiomolbio.2019.11.002

Cytochrome bd in Mycobacterium tuberculosis: A respiratory chain protein involved in the defense against antibacterials

Ludovica Mascolo
, Dirk Bald^*

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

The branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a highly promising target for next-generation antibacterials. This system includes two terminal oxidases of which the exclusively bacterial cytochrome bd represents the less energy-efficient one. Albeit dispensable for growth under standard laboratory conditions, cytochrome bd is important during environmental stress. In this review, we discuss the role of cytochrome bd during infection of the mammalian host and in the defense against antibacterials. Deeper insight into the biochemistry of mycobacterial cytochrome bd is needed to understand the physiological role of this bacteria-specific defense factor. Conversely, cytochrome bd may be utilized to gain information on mycobacterial physiology in vitro and during host infection. Knowledge-based manipulation of cytochrome bd function may assist in designing the next-generation tuberculosis combination chemotherapy.

Original language	English
Pages (from-to)	55-63
Number of pages	9
Journal	Progress in Biophysics and Molecular Biology
Volume	152
Early online date	15 Nov 2019
DOIs	https://doi.org/10.1016/j.pbiomolbio.2019.11.002
Publication status	Published - May 2020

Funding

This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 713669 to the Amsterdam Institute for Molecules, Medicines & systems. The funding agency did not play a role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. The authors wish to thank Holger Lill (VU Amsterdam) for critically reading the manuscript.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antibacterials
Cytochrome bd
Mycobacterium tuberculosis
Respiratory chain

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10.1016/j.pbiomolbio.2019.11.002

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title = "Cytochrome bd in Mycobacterium tuberculosis: A respiratory chain protein involved in the defense against antibacterials",

abstract = "The branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a highly promising target for next-generation antibacterials. This system includes two terminal oxidases of which the exclusively bacterial cytochrome bd represents the less energy-efficient one. Albeit dispensable for growth under standard laboratory conditions, cytochrome bd is important during environmental stress. In this review, we discuss the role of cytochrome bd during infection of the mammalian host and in the defense against antibacterials. Deeper insight into the biochemistry of mycobacterial cytochrome bd is needed to understand the physiological role of this bacteria-specific defense factor. Conversely, cytochrome bd may be utilized to gain information on mycobacterial physiology in vitro and during host infection. Knowledge-based manipulation of cytochrome bd function may assist in designing the next-generation tuberculosis combination chemotherapy.",

keywords = "Antibacterials, Cytochrome bd, Mycobacterium tuberculosis, Respiratory chain",

author = "Ludovica Mascolo and Dirk Bald",

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journal = "Progress in Biophysics and Molecular Biology",

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T1 - Cytochrome bd in Mycobacterium tuberculosis

T2 - A respiratory chain protein involved in the defense against antibacterials

AU - Mascolo, Ludovica

AU - Bald, Dirk

PY - 2020/5

Y1 - 2020/5

N2 - The branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a highly promising target for next-generation antibacterials. This system includes two terminal oxidases of which the exclusively bacterial cytochrome bd represents the less energy-efficient one. Albeit dispensable for growth under standard laboratory conditions, cytochrome bd is important during environmental stress. In this review, we discuss the role of cytochrome bd during infection of the mammalian host and in the defense against antibacterials. Deeper insight into the biochemistry of mycobacterial cytochrome bd is needed to understand the physiological role of this bacteria-specific defense factor. Conversely, cytochrome bd may be utilized to gain information on mycobacterial physiology in vitro and during host infection. Knowledge-based manipulation of cytochrome bd function may assist in designing the next-generation tuberculosis combination chemotherapy.

AB - The branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a highly promising target for next-generation antibacterials. This system includes two terminal oxidases of which the exclusively bacterial cytochrome bd represents the less energy-efficient one. Albeit dispensable for growth under standard laboratory conditions, cytochrome bd is important during environmental stress. In this review, we discuss the role of cytochrome bd during infection of the mammalian host and in the defense against antibacterials. Deeper insight into the biochemistry of mycobacterial cytochrome bd is needed to understand the physiological role of this bacteria-specific defense factor. Conversely, cytochrome bd may be utilized to gain information on mycobacterial physiology in vitro and during host infection. Knowledge-based manipulation of cytochrome bd function may assist in designing the next-generation tuberculosis combination chemotherapy.

KW - Antibacterials

KW - Cytochrome bd

KW - Mycobacterium tuberculosis

KW - Respiratory chain

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U2 - 10.1016/j.pbiomolbio.2019.11.002

DO - 10.1016/j.pbiomolbio.2019.11.002

M3 - Review article

AN - SCOPUS:85076020836

SN - 0079-6107

VL - 152

SP - 55

EP - 63

JO - Progress in Biophysics and Molecular Biology

JF - Progress in Biophysics and Molecular Biology

ER -

Cytochrome bd in Mycobacterium tuberculosis: A respiratory chain protein involved in the defense against antibacterials

Abstract

Funding

UN SDGs

Keywords

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