Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats.

L.W. Wormhoudt, J.P.H.T.M. Ploemen, J.N.M. Commandeur, B. van Ommen, P.J. van Bladeren, N.P.E. Vermeulen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The cytochrome P450 (P450) catalyzed oxidation of 1,2-dibromoethane (1,2-DBE) to 2-bromoacetaldehyde (2-BA) was measured in liver microsomes of both control and differentially induced rats. 2-BA formation was quantified by derivatization of 2-BA with adenosine (ADO), resulting in the formation of the highly fluorescent 1,N
Original languageEnglish
Pages (from-to)41-53
JournalChemico-Biological Interactions
Volume99
DOIs
Publication statusPublished - 1996

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