Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

Sijia Chen; Anton J M De Craen; Yotam Raz; Evelyna Derhovanessian; Ann C T M Vossen; Rudi G J Westendorp; Graham Pawelec; Andrea B. Maier

doi:10.1186/1742-4933-9-18

Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

Sijia Chen, Anton J M De Craen, Yotam Raz, Evelyna Derhovanessian, Ann C T M Vossen, Rudi G J Westendorp, Graham Pawelec, Andrea B. Maier^*

^*Corresponding author for this work

Biomechanics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.

RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).

CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.

Original language	English
Article number	18
Pages (from-to)	1-7
Number of pages	7
Journal	Immunity and Ageing
Volume	9
DOIs	https://doi.org/10.1186/1742-4933-9-18
Publication status	Published - 28 Aug 2012

Keywords

C-reactive protein
Cytomegalovirus
Elderly
HbA1c
IgG antibody level
Non-fasting glucose
Oldest olds
Seropositivity
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1742-4933-9-18

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@article{13ada3230a0446df976313fa1272e126,

title = "Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study",

abstract = "BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.",

keywords = "C-reactive protein, Cytomegalovirus, Elderly, HbA1c, IgG antibody level, Non-fasting glucose, Oldest olds, Seropositivity, Type 2 diabetes",

author = "Sijia Chen and {De Craen}, {Anton J M} and Yotam Raz and Evelyna Derhovanessian and Vossen, {Ann C T M} and Westendorp, {Rudi G J} and Graham Pawelec and Maier, {Andrea B.}",

year = "2012",

month = aug,

day = "28",

doi = "10.1186/1742-4933-9-18",

language = "English",

volume = "9",

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journal = "Immunity and Ageing",

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T1 - Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

AU - Chen, Sijia

AU - De Craen, Anton J M

AU - Raz, Yotam

AU - Derhovanessian, Evelyna

AU - Vossen, Ann C T M

AU - Westendorp, Rudi G J

AU - Pawelec, Graham

AU - Maier, Andrea B.

PY - 2012/8/28

Y1 - 2012/8/28

N2 - BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.

AB - BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.

KW - C-reactive protein

KW - Cytomegalovirus

KW - Elderly

KW - HbA1c

KW - IgG antibody level

KW - Non-fasting glucose

KW - Oldest olds

KW - Seropositivity

KW - Type 2 diabetes

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Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

Abstract

Keywords

UN SDGs

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