Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

Sijia Chen, Anton J M De Craen, Yotam Raz, Evelyna Derhovanessian, Ann C T M Vossen, Rudi G J Westendorp, Graham Pawelec, Andrea B. Maier*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.

RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).

CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.

Original languageEnglish
Article number18
Pages (from-to)1-7
Number of pages7
JournalImmunity and Ageing
Publication statusPublished - 28 Aug 2012



  • C-reactive protein
  • Cytomegalovirus
  • Elderly
  • HbA1c
  • IgG antibody level
  • Non-fasting glucose
  • Oldest olds
  • Seropositivity
  • Type 2 diabetes

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