Cytotoxic T cells in H. pylori-related gastric autoimmunity and gastric lymphoma.

M.P. Bergman, M.M. D'Elios

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Abstract

Helicobacter pylori infection is the major cause of gastroduodenal pathologies, but only a minority of infected patients develop gastric B-cell lymphoma, gastric autoimmunity, or other life threatening diseases, as gastric cancer or peptic ulcer. The type of host immune response against H. pylori, particularly the cytolytic effector functions of T cells, is crucial for the outcome of the infection. T cells are potentially able to kill a target via different mechanisms, such as perforins or Fas-Fas ligand interaction. In H. pylori-infected patients with gastric autoimmunity cytolytic T cells, that cross-recognize different epitopes of H. pylori proteins and H
Original languageEnglish
JournalJournal of Biomedicine and Biotechnology
DOIs
Publication statusPublished - 2010

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