TY - JOUR
T1 - Cytotoxicity of paracetamol and 3,5-dihalgenated analogues: Role of cytochrome P450 and formation of GSH conjugates and protein adducts.
AU - Bessems, J.G.M.
AU - van Stee, L.L.P.
AU - Commandeur, J.N.M.
AU - Groot, E.J.
AU - Vermeulen, N.P.E.
PY - 1997
Y1 - 1997
N2 - The effect of 3,5-dihalogenation of paracetamol (PAR) on the cytotoxicity in rat hepatocytes isolated from 13-naphthoflavone pretreated, non-fasted rats, and the role of cytochrome P-450 in this regard, were studied. On incubation, 3,5-difluoro-PAR, 3,5-dichloro-PAR and 3,5-dibromo-PAR, as well as PAR, caused severe leakage of lactate dehydrogenase (LDH) which was preceded by a rapid concentration- and time-dependent depletion of intracellular glutathione (GSH). IC
AB - The effect of 3,5-dihalogenation of paracetamol (PAR) on the cytotoxicity in rat hepatocytes isolated from 13-naphthoflavone pretreated, non-fasted rats, and the role of cytochrome P-450 in this regard, were studied. On incubation, 3,5-difluoro-PAR, 3,5-dichloro-PAR and 3,5-dibromo-PAR, as well as PAR, caused severe leakage of lactate dehydrogenase (LDH) which was preceded by a rapid concentration- and time-dependent depletion of intracellular glutathione (GSH). IC
U2 - 10.1016/S0887-2333(96)00066-5
DO - 10.1016/S0887-2333(96)00066-5
M3 - Article
SN - 0887-2333
VL - 11
SP - 9
EP - 19
JO - Toxicology in Vitro
JF - Toxicology in Vitro
ER -