Day-to-day fluctuation of schistosome circulating antigen levels in serum and urine of humans infected with Schistosoma mansoni in Burundi

Katja Polman*, Dirk Engels, Lorraine Fathers, Andre M. Deelder, Bruno Gryseels

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Day-to-day fluctuations of both circulating anodic antigen (CAA) and circulating cathodic antigen (CCA) in serum and urine were examined simultaneously in a group of Schistosoma mansoni-infected individuals from Burundi and compared with each other and with fecal egg count fluctuations. Significant correlations were found between fecal egg counts and circulating antigens (CAA and CCA) and between circulating antigen levels in serum and urine samples. The cumulative percentage of positive results after three samplings was highest for urine CCA detection, followed by fecal egg counts, serum CCA, serum CAA, and urine CAA detection, respectively. It was demonstrated that circulating antigen levels in both serum and urine showed less fluctuation than fecal egg counts, except for urine CAA levels. The serum CAA detection assay in particular, although less sensitive in this low endemic area in Burundi, gave very constant measurements over a period of one week. Our results indicate that detection of circulating antigens in a single serum or urine sample provides a quantitatively more stable diagnosis of S. mansoni infection than fecal egg counts based on a single stool examination.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume59
Issue number1
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Dive into the research topics of 'Day-to-day fluctuation of schistosome circulating antigen levels in serum and urine of humans infected with Schistosoma mansoni in Burundi'. Together they form a unique fingerprint.

Cite this