Decreased gray matter diffusivity: a potential early Alzheimer disease biomarker?

H.I.L. Jacobs, M.P.J. van Boxtel, E.H.B.M. Gronenschild, H.B.M. Uylings, J. Jolles, F.R.J. Verhey

    Research output: Contribution to JournalArticleAcademicpeer-review


    Background: Gray matter atrophy, an important biomarker for early Alzheimer's disease, might be due to white matter changes within gray matter. Methods: Twenty older participants with significant memory decline over a 12-year period (T12) were matched to 20 nondeclining participants. All participants were magnetic resonance imaging scanned at T12. Cortical thickness and diffusion tensor imaging analyses were performed. Results: Lower cortical thickness values were associated with lower diffusion values in frontal and parietal gray matter areas. This association was only present in the memory decline group. The cortical thickness-diffusion tensor imaging correlations showed significant group differences in the posterior cingulate gyrus, precuneus, and superior frontal gyrus. Conclusions: Decreased gray matter diffusivity in the posterior cingulate/precuneus area might be a disease-specific process and a potential new biomarker for early Alzheimer's disease. Future studies should validate its potential as a biomarker and focus on cellular changes underlying diffusivity changes in gray matter. © 2013 The Alzheimer's Association. All rights reserved.
    Original languageEnglish
    Pages (from-to)93-97
    JournalAlzheimers & Dementia
    Issue number1
    Publication statusPublished - 2013


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