Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5

R.A. Floto; P.A. MacAry; J.M. Boname; T.S. Mien; B. Kampmann; J.R. Hair; O.S. Huey; E.N.G. Houben; J. Pieters; C. Day; W. Oehlmann; M. Singh; K.G. Smith; P.J. Lehner

doi:10.1126/science.1133515

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5

R.A. Floto, P.A. MacAry, J.M. Boname, T.S. Mien, B. Kampmann, J.R. Hair, O.S. Huey, E.N.G. Houben, J. Pieters, C. Day, W. Oehlmann, M. Singh, K.G. Smith, P.J. Lehner

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

An effective host immune response to mycobacterial infection must control pathogen dissemination without inducing immunopathology. Constitutive overexpression of mycobacterial heat shock protein (myHsp70) is associated with impaired bacterial persistence, but the immune-mediated mechanisms are unknown. We found that myHsp70, in addition to enhancing antigen delivery to human dendritic cells, signaled through the CCR5 chemokine receptor, promoting dendritic cell aggregation, immune synapse formation between dendritic cells and T cells, and the generation of effector immune responses. Thus, CCR5 acts as a pattern-recognition receptor for myHsp70, which may have implications for both the pathophysiology of tuberculosis and the use of myHsps in tumor-directed immunotherapy.

Original language	English
Pages (from-to)	454-458
Journal	Science
Volume	2006
Issue number	314
DOIs	https://doi.org/10.1126/science.1133515
Publication status	Published - 2006

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title = "Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5",

abstract = "An effective host immune response to mycobacterial infection must control pathogen dissemination without inducing immunopathology. Constitutive overexpression of mycobacterial heat shock protein (myHsp70) is associated with impaired bacterial persistence, but the immune-mediated mechanisms are unknown. We found that myHsp70, in addition to enhancing antigen delivery to human dendritic cells, signaled through the CCR5 chemokine receptor, promoting dendritic cell aggregation, immune synapse formation between dendritic cells and T cells, and the generation of effector immune responses. Thus, CCR5 acts as a pattern-recognition receptor for myHsp70, which may have implications for both the pathophysiology of tuberculosis and the use of myHsps in tumor-directed immunotherapy.",

author = "R.A. Floto and P.A. MacAry and J.M. Boname and T.S. Mien and B. Kampmann and J.R. Hair and O.S. Huey and E.N.G. Houben and J. Pieters and C. Day and W. Oehlmann and M. Singh and K.G. Smith and P.J. Lehner",

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doi = "10.1126/science.1133515",

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T1 - Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5

AU - Floto, R.A.

AU - MacAry, P.A.

AU - Boname, J.M.

AU - Mien, T.S.

AU - Kampmann, B.

AU - Hair, J.R.

AU - Huey, O.S.

AU - Houben, E.N.G.

AU - Pieters, J.

AU - Day, C.

AU - Oehlmann, W.

AU - Singh, M.

AU - Smith, K.G.

AU - Lehner, P.J.

PY - 2006

Y1 - 2006

N2 - An effective host immune response to mycobacterial infection must control pathogen dissemination without inducing immunopathology. Constitutive overexpression of mycobacterial heat shock protein (myHsp70) is associated with impaired bacterial persistence, but the immune-mediated mechanisms are unknown. We found that myHsp70, in addition to enhancing antigen delivery to human dendritic cells, signaled through the CCR5 chemokine receptor, promoting dendritic cell aggregation, immune synapse formation between dendritic cells and T cells, and the generation of effector immune responses. Thus, CCR5 acts as a pattern-recognition receptor for myHsp70, which may have implications for both the pathophysiology of tuberculosis and the use of myHsps in tumor-directed immunotherapy.

AB - An effective host immune response to mycobacterial infection must control pathogen dissemination without inducing immunopathology. Constitutive overexpression of mycobacterial heat shock protein (myHsp70) is associated with impaired bacterial persistence, but the immune-mediated mechanisms are unknown. We found that myHsp70, in addition to enhancing antigen delivery to human dendritic cells, signaled through the CCR5 chemokine receptor, promoting dendritic cell aggregation, immune synapse formation between dendritic cells and T cells, and the generation of effector immune responses. Thus, CCR5 acts as a pattern-recognition receptor for myHsp70, which may have implications for both the pathophysiology of tuberculosis and the use of myHsps in tumor-directed immunotherapy.

U2 - 10.1126/science.1133515

DO - 10.1126/science.1133515

M3 - Article

SN - 0036-8075

VL - 2006

SP - 454

EP - 458

JO - Science

JF - Science

IS - 314

ER -

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5

Abstract

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