Dental Alloy-associated Innate Immune Response

Dessy Rachmawati, Cornelis J. Kleverlaan

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Abstract

The number of metals to which humans are exposed has sharply increased during the 20th century. In dentistry, usually alloys are a mixture of two or more metals. Classification of dental alloys has recently been renewed after the introduction of titanium (Ti) and Ti alloys. This chapter describes the effects of a broad panel of orally applied metals and alloys on the human immune system with a focus on innate responsiveness and early inflammatory events. Noble metal-based alloys have the longest history of use in dentistry. High noble and noble alloys, in particular gold, platinum and palladium, were increasingly used because of their physical and mechanical properties. Despite the fact that the gastrointestinal tract is known as a tolerogenic entry route for foreign proteins and chemicals, oral exposure to dental alloys has often been associated with local or even systemic adverse reactions.

Original languageEnglish
Title of host publicationImmunology for Dentistry
EditorsMohammad Tariqur Rahman, Wim Teughels, Richard J. Lamont
PublisherWiley
Chapter12
Pages165-186
Number of pages22
ISBN (Electronic)9781119893035
ISBN (Print)9781119893004
DOIs
Publication statusPublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 John Wiley & Sons Ltd. All rights reserved.

Keywords

  • Dental alloys
  • Gastrointestinal tract
  • Human immune system
  • Innate responsiveness
  • Mechanical properties
  • Noble alloys
  • Systemic adverse reactions
  • Titanium alloys

Fingerprint

Dive into the research topics of 'Dental Alloy-associated Innate Immune Response'. Together they form a unique fingerprint.

Cite this