Dental implants in dentate primary and secondary Sjögren's syndrome patients: A multicenter prospective cohort study

Floor Maarse; Willem M.M. Fennis; Jos W.R. Twisk; Anke Korfage; Hendrik J Santing; Laurens den Hartog; Marvick S.M. Muradin; Melvin S Maningky; Gerry M. Raghoebar; Arjan Vissink; Henk S. Brand; Derk Hendrik Jan Jager

doi:10.1111/clr.13998

Dental implants in dentate primary and secondary Sjögren's syndrome patients: A multicenter prospective cohort study

Floor Maarse, Willem M.M. Fennis, Jos W.R. Twisk, Anke Korfage, Hendrik J Santing, Laurens den Hartog, Marvick S.M. Muradin, Melvin S Maningky, Gerry M. Raghoebar, Arjan Vissink, Henk S. Brand, Derk Hendrik Jan Jager^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objectives: To prospectively assess the clinical performance and patient-reported outcomes of dental implants in dentate patients with primary and secondary Sjögren's syndrome (pSS and sSS, respectively) compared to patients without SS. Materials and Methods: Thirty-seven implants were placed in 17 patients with pSS/sSS and 26 implants in 17 non-SS patients to replace missing (pre)molars. Clinical performance, marginal bone-level changes, patient satisfaction, and oral health-related quality of life (OHRQoL) were assessed at 1 (T1), 6 (T6), 12 (T12), and 18 (T18) months after placement of the superstructure. Marginal bone-level changes were measured on standardized dental radiographs. Clinical parameters included implant and crown survival, plaque, bleeding and gingival indices, and probing depth. Patient satisfaction and OHRQoL were assessed with validated questionnaires. Results: Implant survival at T18 was 100% in the patients with pSS/sSS and 96.2% in the non-SS group. Mean marginal bone loss at T18 did not differ between patients with pSS/sSS and non-SS patients, 1.10 ± 1.04 and 1.04 ± 0.75 mm, respectively (p =.87). Clinical performance was good with no differences between the groups for all outcome measures (p >.05). OHRQoL in patients with pSS/sSS had improved significantly after placement of implant supported crowns at all measuring moments compared to baseline (p <.05). Nevertheless, patient satisfaction and OHRQoL remained significantly higher for patients without SS at all measuring moments (p <.05). Conclusion: Dental implants can be successfully applied in dentate patients with pSS/sSS and have a positive effect on OHRQoL.

Original language	English
Pages (from-to)	1157-1170
Number of pages	14
Journal	Clinical Oral Implants Research
Volume	33
Issue number	11
Early online date	22 Sept 2022
DOIs	https://doi.org/10.1111/clr.13998
Publication status	Published - Nov 2022

Bibliographical note

Funding Information:
This study was funded by unconditional research grants from Foundation NutsOhra (FNO), Amsterdam, the Netherlands and Biohorizons Inc, Birmingham, AL, USA. No other conflicts of interest can be identified. We would like to thank all the participants of this study. We also like to thank Maxillofacial Dental Laboratory G. van Dijk, Groningen, the Netherlands, for fabricating the individualized X‐ray holders and superstructures.

Publisher Copyright:
© 2022 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.

Funding

This study was funded by unconditional research grants from Foundation NutsOhra (FNO), Amsterdam, the Netherlands and Biohorizons Inc, Birmingham, AL, USA. No other conflicts of interest can be identified. We would like to thank all the participants of this study. We also like to thank Maxillofacial Dental Laboratory G. van Dijk, Groningen, the Netherlands, for fabricating the individualized X‐ray holders and superstructures.

Funders	Funder number
Maxillofacial Dental Laboratory G. van Dijk, Groningen
Fonds NutsOhra

Keywords

dental implants
prosthodontics
Sjögren's syndrome
xerostomia

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Maarse, F., Fennis, W. M. M., Twisk, J. W. R., Korfage, A., Santing, HJ., den Hartog, L., Muradin, M. S. M., Maningky, MS., Raghoebar, G. M., Vissink, A., Brand, H. S., & Jager, D. H. J. (2022). Dental implants in dentate primary and secondary Sjögren's syndrome patients: A multicenter prospective cohort study. Clinical Oral Implants Research, 33(11), 1157-1170. https://doi.org/10.1111/clr.13998

@article{81b58084363f4148902f27ef72fb75ba,

title = "Dental implants in dentate primary and secondary Sj{\"o}gren's syndrome patients: A multicenter prospective cohort study",

abstract = "Objectives: To prospectively assess the clinical performance and patient-reported outcomes of dental implants in dentate patients with primary and secondary Sj{\"o}gren's syndrome (pSS and sSS, respectively) compared to patients without SS. Materials and Methods: Thirty-seven implants were placed in 17 patients with pSS/sSS and 26 implants in 17 non-SS patients to replace missing (pre)molars. Clinical performance, marginal bone-level changes, patient satisfaction, and oral health-related quality of life (OHRQoL) were assessed at 1 (T1), 6 (T6), 12 (T12), and 18 (T18) months after placement of the superstructure. Marginal bone-level changes were measured on standardized dental radiographs. Clinical parameters included implant and crown survival, plaque, bleeding and gingival indices, and probing depth. Patient satisfaction and OHRQoL were assessed with validated questionnaires. Results: Implant survival at T18 was 100\% in the patients with pSS/sSS and 96.2\% in the non-SS group. Mean marginal bone loss at T18 did not differ between patients with pSS/sSS and non-SS patients, 1.10 ± 1.04 and 1.04 ± 0.75 mm, respectively (p =.87). Clinical performance was good with no differences between the groups for all outcome measures (p >.05). OHRQoL in patients with pSS/sSS had improved significantly after placement of implant supported crowns at all measuring moments compared to baseline (p <.05). Nevertheless, patient satisfaction and OHRQoL remained significantly higher for patients without SS at all measuring moments (p <.05). Conclusion: Dental implants can be successfully applied in dentate patients with pSS/sSS and have a positive effect on OHRQoL.",

keywords = "dental implants, prosthodontics, Sj{\"o}gren's syndrome, xerostomia",

author = "Floor Maarse and Fennis, \{Willem M.M.\} and Twisk, \{Jos W.R.\} and Anke Korfage and Hendrik J Santing and \{den Hartog\}, Laurens and Muradin, \{Marvick S.M.\} and Melvin S Maningky and Raghoebar, \{Gerry M.\} and Arjan Vissink and Brand, \{Henk S.\} and Jager, \{Derk Hendrik Jan\}",

note = "Funding Information: This study was funded by unconditional research grants from Foundation NutsOhra (FNO), Amsterdam, the Netherlands and Biohorizons Inc, Birmingham, AL, USA. No other conflicts of interest can be identified. We would like to thank all the participants of this study. We also like to thank Maxillofacial Dental Laboratory G. van Dijk, Groningen, the Netherlands, for fabricating the individualized X‐ray holders and superstructures. Publisher Copyright: {\textcopyright} 2022 The Authors. Clinical Oral Implants Research published by John Wiley \& Sons Ltd.",

year = "2022",

month = nov,

doi = "10.1111/clr.13998",

language = "English",

volume = "33",

pages = "1157--1170",

journal = "Clinical Oral Implants Research",

issn = "0905-7161",

publisher = "Blackwell Munksgaard",

number = "11",

}

Maarse, F, Fennis, WMM, Twisk, JWR, Korfage, A, Santing, HJ, den Hartog, L, Muradin, MSM, Maningky, MS, Raghoebar, GM, Vissink, A, Brand, HS & Jager, DHJ 2022, 'Dental implants in dentate primary and secondary Sjögren's syndrome patients: A multicenter prospective cohort study', Clinical Oral Implants Research, vol. 33, no. 11, pp. 1157-1170. https://doi.org/10.1111/clr.13998

TY - JOUR

T1 - Dental implants in dentate primary and secondary Sjögren's syndrome patients

T2 - A multicenter prospective cohort study

AU - Maarse, Floor

AU - Fennis, Willem M.M.

AU - Twisk, Jos W.R.

AU - Korfage, Anke

AU - Santing, Hendrik J

AU - den Hartog, Laurens

AU - Muradin, Marvick S.M.

AU - Maningky, Melvin S

AU - Raghoebar, Gerry M.

AU - Vissink, Arjan

AU - Brand, Henk S.

AU - Jager, Derk Hendrik Jan

N1 - Funding Information: This study was funded by unconditional research grants from Foundation NutsOhra (FNO), Amsterdam, the Netherlands and Biohorizons Inc, Birmingham, AL, USA. No other conflicts of interest can be identified. We would like to thank all the participants of this study. We also like to thank Maxillofacial Dental Laboratory G. van Dijk, Groningen, the Netherlands, for fabricating the individualized X‐ray holders and superstructures. Publisher Copyright: © 2022 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.

PY - 2022/11

Y1 - 2022/11

N2 - Objectives: To prospectively assess the clinical performance and patient-reported outcomes of dental implants in dentate patients with primary and secondary Sjögren's syndrome (pSS and sSS, respectively) compared to patients without SS. Materials and Methods: Thirty-seven implants were placed in 17 patients with pSS/sSS and 26 implants in 17 non-SS patients to replace missing (pre)molars. Clinical performance, marginal bone-level changes, patient satisfaction, and oral health-related quality of life (OHRQoL) were assessed at 1 (T1), 6 (T6), 12 (T12), and 18 (T18) months after placement of the superstructure. Marginal bone-level changes were measured on standardized dental radiographs. Clinical parameters included implant and crown survival, plaque, bleeding and gingival indices, and probing depth. Patient satisfaction and OHRQoL were assessed with validated questionnaires. Results: Implant survival at T18 was 100% in the patients with pSS/sSS and 96.2% in the non-SS group. Mean marginal bone loss at T18 did not differ between patients with pSS/sSS and non-SS patients, 1.10 ± 1.04 and 1.04 ± 0.75 mm, respectively (p =.87). Clinical performance was good with no differences between the groups for all outcome measures (p >.05). OHRQoL in patients with pSS/sSS had improved significantly after placement of implant supported crowns at all measuring moments compared to baseline (p <.05). Nevertheless, patient satisfaction and OHRQoL remained significantly higher for patients without SS at all measuring moments (p <.05). Conclusion: Dental implants can be successfully applied in dentate patients with pSS/sSS and have a positive effect on OHRQoL.

AB - Objectives: To prospectively assess the clinical performance and patient-reported outcomes of dental implants in dentate patients with primary and secondary Sjögren's syndrome (pSS and sSS, respectively) compared to patients without SS. Materials and Methods: Thirty-seven implants were placed in 17 patients with pSS/sSS and 26 implants in 17 non-SS patients to replace missing (pre)molars. Clinical performance, marginal bone-level changes, patient satisfaction, and oral health-related quality of life (OHRQoL) were assessed at 1 (T1), 6 (T6), 12 (T12), and 18 (T18) months after placement of the superstructure. Marginal bone-level changes were measured on standardized dental radiographs. Clinical parameters included implant and crown survival, plaque, bleeding and gingival indices, and probing depth. Patient satisfaction and OHRQoL were assessed with validated questionnaires. Results: Implant survival at T18 was 100% in the patients with pSS/sSS and 96.2% in the non-SS group. Mean marginal bone loss at T18 did not differ between patients with pSS/sSS and non-SS patients, 1.10 ± 1.04 and 1.04 ± 0.75 mm, respectively (p =.87). Clinical performance was good with no differences between the groups for all outcome measures (p >.05). OHRQoL in patients with pSS/sSS had improved significantly after placement of implant supported crowns at all measuring moments compared to baseline (p <.05). Nevertheless, patient satisfaction and OHRQoL remained significantly higher for patients without SS at all measuring moments (p <.05). Conclusion: Dental implants can be successfully applied in dentate patients with pSS/sSS and have a positive effect on OHRQoL.

KW - dental implants

KW - prosthodontics

KW - Sjögren's syndrome

KW - xerostomia

UR - https://www.scopus.com/pages/publications/85139443765

UR - https://www.scopus.com/inward/citedby.url?scp=85139443765&partnerID=8YFLogxK

U2 - 10.1111/clr.13998

DO - 10.1111/clr.13998

M3 - Article

AN - SCOPUS:85139443765

SN - 0905-7161

VL - 33

SP - 1157

EP - 1170

JO - Clinical Oral Implants Research

JF - Clinical Oral Implants Research

IS - 11

ER -

Dental implants in dentate primary and secondary Sjögren's syndrome patients: A multicenter prospective cohort study

Abstract

Bibliographical note

Funding

Keywords

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