Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor

S. Nijmeijer, H. Engelhardt, S. Schultes, A. van de Stolpe, V. Lusink, C. de Graaf, M. Wijtmans, E.E. Haaksma, I.J.P. de Esch, K. Stachurski, H.F. Vischer, R. Leurs

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H
Original languageEnglish
Pages (from-to)89-100
JournalBritish Journal of Pharmacology
Volume2013
Issue number170
DOIs
Publication statusPublished - 2013

Fingerprint

Histamine
Cysteine
Pharmacology
human HRH4 protein
4-(4-methylpiperazin-1-yl)-6-phenyl-2-vinylpyrimidine
2-aminopyrimidine

Cite this

@article{5d73cb778dc14640b56cb8b8c07763e2,
title = "Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor",
abstract = "Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H",
author = "S. Nijmeijer and H. Engelhardt and S. Schultes and {van de Stolpe}, A. and V. Lusink and {de Graaf}, C. and M. Wijtmans and E.E. Haaksma and {de Esch}, I.J.P. and K. Stachurski and H.F. Vischer and R. Leurs",
year = "2013",
doi = "10.1111/bph.12113",
language = "English",
volume = "2013",
pages = "89--100",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley-Blackwell",
number = "170",

}

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor. / Nijmeijer, S.; Engelhardt, H.; Schultes, S.; van de Stolpe, A.; Lusink, V.; de Graaf, C.; Wijtmans, M.; Haaksma, E.E.; de Esch, I.J.P.; Stachurski, K.; Vischer, H.F.; Leurs, R.

In: British Journal of Pharmacology, Vol. 2013, No. 170, 2013, p. 89-100.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor

AU - Nijmeijer, S.

AU - Engelhardt, H.

AU - Schultes, S.

AU - van de Stolpe, A.

AU - Lusink, V.

AU - de Graaf, C.

AU - Wijtmans, M.

AU - Haaksma, E.E.

AU - de Esch, I.J.P.

AU - Stachurski, K.

AU - Vischer, H.F.

AU - Leurs, R.

PY - 2013

Y1 - 2013

N2 - Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H

AB - Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H

U2 - 10.1111/bph.12113

DO - 10.1111/bph.12113

M3 - Article

VL - 2013

SP - 89

EP - 100

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 170

ER -