Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor

S. Nijmeijer; H. Engelhardt; S. Schultes; A. van de Stolpe; V. Lusink; C. de Graaf; M. Wijtmans; E.E. Haaksma; I.J.P. de Esch; K. Stachurski; H.F. Vischer; R. Leurs

doi:10.1111/bph.12113

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor

S. Nijmeijer, H. Engelhardt, S. Schultes, A. van de Stolpe, V. Lusink, C. de Graaf, M. Wijtmans, E.E. Haaksma, I.J.P. de Esch, K. Stachurski, H.F. Vischer, R. Leurs

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H

Original language	English
Pages (from-to)	89-100
Journal	British Journal of Pharmacology
Volume	2013
Issue number	170
DOIs	https://doi.org/10.1111/bph.12113
Publication status	Published - 2013

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Nijmeijer, S., Engelhardt, H., Schultes, S., van de Stolpe, A., Lusink, V., de Graaf, C., Wijtmans, M., Haaksma, E. E., de Esch, I. J. P., Stachurski, K., Vischer, H. F., & Leurs, R. (2013). Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor. British Journal of Pharmacology, 2013(170), 89-100. https://doi.org/10.1111/bph.12113

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title = "Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor",

abstract = "Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H",

author = "S. Nijmeijer and H. Engelhardt and S. Schultes and \{van de Stolpe\}, A. and V. Lusink and \{de Graaf\}, C. and M. Wijtmans and E.E. Haaksma and \{de Esch\}, I.J.P. and K. Stachurski and H.F. Vischer and R. Leurs",

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doi = "10.1111/bph.12113",

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volume = "2013",

pages = "89--100",

journal = "British Journal of Pharmacology",

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Nijmeijer, S, Engelhardt, H, Schultes, S, van de Stolpe, A, Lusink, V, de Graaf, C, Wijtmans, M, Haaksma, EE, de Esch, IJP, Stachurski, K, Vischer, HF & Leurs, R 2013, 'Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor', British Journal of Pharmacology, vol. 2013, no. 170, pp. 89-100. https://doi.org/10.1111/bph.12113

TY - JOUR

T1 - Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor

AU - Nijmeijer, S.

AU - Engelhardt, H.

AU - Schultes, S.

AU - van de Stolpe, A.

AU - Lusink, V.

AU - de Graaf, C.

AU - Wijtmans, M.

AU - Haaksma, E.E.

AU - de Esch, I.J.P.

AU - Stachurski, K.

AU - Vischer, H.F.

AU - Leurs, R.

PY - 2013

Y1 - 2013

N2 - Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H

AB - Background and Purpose The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H

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U2 - 10.1111/bph.12113

DO - 10.1111/bph.12113

M3 - Article

SN - 0007-1188

VL - 2013

SP - 89

EP - 100

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 170

ER -

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor

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