Design and Preparation of New Ligands Interacting with the Histamine H4 Receptor

Research output: PhD Thesis › PhD-Thesis - Research and graduation internal

3108 Downloads (Pure)

Original language	English
Qualification	PhD
Awarding Institution	Vrije Universiteit Amsterdam
Supervisors/Advisors	Leurs, Rob, Supervisor Haaksma, E.J.J., Supervisor de Esch, Iwan, Co-supervisor
Award date	18 Dec 2013
Publication status	Published - 2013

Access to Document

CoverFinal published version, 2.86 MB
Title pageFinal published version, 18.8 KB
Abstract dutchFinal published version, 2.07 MB
Abstract englishFinal published version, 2.21 MB
Table of contentsFinal published version, 8.13 KB
Chapter 1 Aim and outline of thesisFinal published version, 37.8 KB
Chapter 2 Overview of H4R antagonistsFinal published version, 203 KB
Chapter 3 Detailed SAR of indolecarboxamides as H4 receptor ligandsFinal published version, 2.02 MB
Chapter 5 Characterization of a covalent hH4R partial agonistFinal published version, 12.8 MB
Chapter 7 Triazoloquinoxalines as potent histamine H4 receptor ligandsFinal published version, 1.41 MB
Chapter 8 SummaryFinal published version, 2.21 MB
Appendix 1 List of publicationsFinal published version, 14.5 KB
Appendix 2 Curriculum VitaeFinal published version, 69.8 KB
Appendix 3 List of AbbreviationsFinal published version, 16 KB
Appendix 4 AcknowledgmentFinal published version, 8.3 KB

Chapter 4 Elucidation of H4R-Pyrimidine Binding Modes
Final published version, 5.49 MB
Embargo ends: 1/01/50

Chapter 6 Bispyrimidines as potent histamine H4 receptor ligands
Final published version, 3.58 MB
Embargo ends: 1/01/50