Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

W.A. van Gemert; J.I. Iestra; A.J. Schuit; A.M. May; T. Takken; W.B. Veldhuis; J. van der Palen; H. Wittink; P.H. Peeters; E.M. Monnikhof

doi:10.1186/1471-2407-13-395

Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

W.A. van Gemert, J.I. Iestra, A.J. Schuit, A.M. May, T. Takken, W.B. Veldhuis, J. van der Palen, H. Wittink, P.H. Peeters, E.M. Monnikhof

Prevention and Public Health

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached.The aim of this study is to investigate the effect attributable to exercise on postmenopausal breast cancer risk biomarkers, when equivalent weight loss is achieved compared with diet-induced weight loss.Design: The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25-35 kg/m

Original language	English
Article number	395
Journal	BMC Cancer
Volume	13
DOIs	https://doi.org/10.1186/1471-2407-13-395
Publication status	Published - 2013

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van Gemert, W. A., Iestra, J. I., Schuit, A. J., May, A. M., Takken, T., Veldhuis, W. B., van der Palen, J., Wittink, H., Peeters, P. H., & Monnikhof, E. M. (2013). Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk. BMC Cancer, 13, Article 395. https://doi.org/10.1186/1471-2407-13-395

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title = "Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk",

abstract = "Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached.The aim of this study is to investigate the effect attributable to exercise on postmenopausal breast cancer risk biomarkers, when equivalent weight loss is achieved compared with diet-induced weight loss.Design: The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25-35 kg/m",

author = "{van Gemert}, W.A. and J.I. Iestra and A.J. Schuit and A.M. May and T. Takken and W.B. Veldhuis and {van der Palen}, J. and H. Wittink and P.H. Peeters and E.M. Monnikhof",

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AU - van Gemert, W.A.

AU - Iestra, J.I.

AU - Schuit, A.J.

AU - May, A.M.

AU - Takken, T.

AU - Veldhuis, W.B.

AU - van der Palen, J.

AU - Wittink, H.

AU - Peeters, P.H.

AU - Monnikhof, E.M.

PY - 2013

Y1 - 2013

N2 - Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached.The aim of this study is to investigate the effect attributable to exercise on postmenopausal breast cancer risk biomarkers, when equivalent weight loss is achieved compared with diet-induced weight loss.Design: The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25-35 kg/m

AB - Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight was achieved. The question remains whether there is an additional beneficial effect of physical activity when weight loss is reached.The aim of this study is to investigate the effect attributable to exercise on postmenopausal breast cancer risk biomarkers, when equivalent weight loss is achieved compared with diet-induced weight loss.Design: The SHAPE-2 study is a three-armed, multicentre trial. 243 sedentary, postmenopausal women who are overweight or obese (BMI 25-35 kg/m

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DO - 10.1186/1471-2407-13-395

M3 - Article

SN - 1471-2407

VL - 13

JO - BMC Cancer

JF - BMC Cancer

M1 - 395

ER -

Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

Abstract

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