Detailed structure-activity relationship of indolecarboxamides as H(4) receptor ligands

H. Engelhardt; I.J.P. de Esch; D. Kuhn; R.A. Smits; O.P. Zuiderveld; J. Dobler; M. Mayer; S. Lips; H. Arnhof; D. Scharn; E.E. Haaksma; R. Leurs

doi:10.1016/j.ejmech.2012.06.016

Detailed structure-activity relationship of indolecarboxamides as H(4) receptor ligands

H. Engelhardt
, I.J.P. de Esch
, D. Kuhn
, R.A. Smits
, O.P. Zuiderveld
, J. Dobler
, M. Mayer
, S. Lips
, H. Arnhof
, D. Scharn
, E.E. Haaksma
, R. Leurs

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A series of 76 derivatives of the indolecarboxamide 1 were synthesized, which allows a detailed SAR investigation of this well known scaffold. The data enable the definition of a predictive QSAR model which identifies several compounds with an activity comparable to 1. A selection of these new H

Original language	English
Pages (from-to)	660-668
Journal	European Journal of Medicinal Chemistry
Volume	54
DOIs	https://doi.org/10.1016/j.ejmech.2012.06.016
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 6 Clean Water and Sanitation

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10.1016/j.ejmech.2012.06.016

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title = "Detailed structure-activity relationship of indolecarboxamides as H(4) receptor ligands",

abstract = "A series of 76 derivatives of the indolecarboxamide 1 were synthesized, which allows a detailed SAR investigation of this well known scaffold. The data enable the definition of a predictive QSAR model which identifies several compounds with an activity comparable to 1. A selection of these new H",

author = "H. Engelhardt and \{de Esch\}, I.J.P. and D. Kuhn and R.A. Smits and O.P. Zuiderveld and J. Dobler and M. Mayer and S. Lips and H. Arnhof and D. Scharn and E.E. Haaksma and R. Leurs",

year = "2012",

doi = "10.1016/j.ejmech.2012.06.016",

language = "English",

volume = "54",

pages = "660--668",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

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T1 - Detailed structure-activity relationship of indolecarboxamides as H(4) receptor ligands

AU - Engelhardt, H.

AU - de Esch, I.J.P.

AU - Kuhn, D.

AU - Smits, R.A.

AU - Zuiderveld, O.P.

AU - Dobler, J.

AU - Mayer, M.

AU - Lips, S.

AU - Arnhof, H.

AU - Scharn, D.

AU - Haaksma, E.E.

AU - Leurs, R.

PY - 2012

Y1 - 2012

N2 - A series of 76 derivatives of the indolecarboxamide 1 were synthesized, which allows a detailed SAR investigation of this well known scaffold. The data enable the definition of a predictive QSAR model which identifies several compounds with an activity comparable to 1. A selection of these new H

AB - A series of 76 derivatives of the indolecarboxamide 1 were synthesized, which allows a detailed SAR investigation of this well known scaffold. The data enable the definition of a predictive QSAR model which identifies several compounds with an activity comparable to 1. A selection of these new H

U2 - 10.1016/j.ejmech.2012.06.016

DO - 10.1016/j.ejmech.2012.06.016

M3 - Article

SN - 0223-5234

VL - 54

SP - 660

EP - 668

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Detailed structure-activity relationship of indolecarboxamides as H(4) receptor ligands

Abstract

UN SDGs

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