TY - JOUR
T1 - Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy
AU - Knaapen, P.
AU - Germans, T.
AU - Camici, P.G.
AU - Rimoldi, O.E.
AU - ten Cate, F.J.
AU - ten Berg, J.M.
AU - Dijkmans, P.A.
AU - Boellaard, R.
AU - van Dockum, W.G.
AU - Gotte, M.J.W.
AU - Twisk, J.W.R.
AU - van Rossum, A.C.
AU - Lammertsma, A.A.
AU - Visser, F.C.
PY - 2008
Y1 - 2008
N2 - Impaired hyperemic myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM), despite normal epicardial coronary arteries, results in microvascular dysfunction. The aim of the present study was to determine the relative contribution of extravascular compressive forces to microvascular dysfunction in HCM. Eighteen patients with symptomatic HCM and normal coronary arteries and 10 age-matched healthy volunteers were studied with PET to quantify resting and hyperemic MBF at a subendocardial and subepicardial level. In HCM patients, MRI was performed to determine left ventricular (LV) mass index (LVMI) and volumes, echocardiography to assess diastolic perfusion time, heart catheterization to measure LV outflow tract gradient (LVOTG) and LV pressures, and serum NH
AB - Impaired hyperemic myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM), despite normal epicardial coronary arteries, results in microvascular dysfunction. The aim of the present study was to determine the relative contribution of extravascular compressive forces to microvascular dysfunction in HCM. Eighteen patients with symptomatic HCM and normal coronary arteries and 10 age-matched healthy volunteers were studied with PET to quantify resting and hyperemic MBF at a subendocardial and subepicardial level. In HCM patients, MRI was performed to determine left ventricular (LV) mass index (LVMI) and volumes, echocardiography to assess diastolic perfusion time, heart catheterization to measure LV outflow tract gradient (LVOTG) and LV pressures, and serum NH
UR - https://www.scopus.com/pages/publications/39149115697
UR - https://www.scopus.com/inward/citedby.url?scp=39149115697&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.00233.2007
DO - 10.1152/ajpheart.00233.2007
M3 - Article
SN - 0363-6135
VL - 294
SP - H986-H993
JO - American Journal of Physiology. Heart and Circulatory Physiology
JF - American Journal of Physiology. Heart and Circulatory Physiology
IS - 2
ER -
