TY - JOUR
T1 - DETERMINATION OF METHYLPHOSPHONIC ACID AND ALKYL METHYLPHOSPHONIC ACID ESTERS IN SOILS BY LIQUID CHROMATOGRAPHY-HIGH-RESOLUTION MASS SPECTROMETRY (LC-HRMS) Определение метилфосфоновой кислоты и ее алкиловых эфиров в почве методом жидкостной хромато-масс-спектрометрии высокого разрешения
AU - Vokuev, M.F.
AU - Braun, A.V.
AU - Baygildiev, T.M.
AU - Rybalchenko, I.V.
AU - Rodin, I.A.
PY - 2022
Y1 - 2022
N2 - © 2022 Industrial Laboratory. Materials Diagnostics. Series Transport. All rights reserved.We have optimized the method for simultaneous extraction of ethyl methylphosphonic acid ester (EMPA), isopropyl methylphosphonic acid ester (IPMPA), isobutyl methylphosphonic acid ester (IBMPA), pinacolyl methylphosphonic acid ester (PMPA), and methylphosphonic acid (MPA) from soil with their further determination by high performance liquid chromatography — high-resolution tandem mass spectrometry (HPLC — HRMS/MS). The analytes are highly-polar products of nerve agent hydrolysis. The observed ions in the fragmentation mass spectra of deprotonated molecules of EMPA, IPMPA, IBMPA, PMPA, MPA, and their corresponding deuterated molecules, as well as possible structural formulas of fragment ions are presented. Liquid extraction with deionized water followed by concentration by evaporation is used to prepare soil samples for analysis. Separation of the components was carried out using reverse-phase chromatography. The time required for sample preparation and analysis of soil samples does not exceed 1 hour. The detection limits in soil were 0.05 ng/g for EMPA and IPMPA, 0.02 ng/g for IBMPA and PMPA, and 1 ng/g for MPA.
AB - © 2022 Industrial Laboratory. Materials Diagnostics. Series Transport. All rights reserved.We have optimized the method for simultaneous extraction of ethyl methylphosphonic acid ester (EMPA), isopropyl methylphosphonic acid ester (IPMPA), isobutyl methylphosphonic acid ester (IBMPA), pinacolyl methylphosphonic acid ester (PMPA), and methylphosphonic acid (MPA) from soil with their further determination by high performance liquid chromatography — high-resolution tandem mass spectrometry (HPLC — HRMS/MS). The analytes are highly-polar products of nerve agent hydrolysis. The observed ions in the fragmentation mass spectra of deprotonated molecules of EMPA, IPMPA, IBMPA, PMPA, MPA, and their corresponding deuterated molecules, as well as possible structural formulas of fragment ions are presented. Liquid extraction with deionized water followed by concentration by evaporation is used to prepare soil samples for analysis. Separation of the components was carried out using reverse-phase chromatography. The time required for sample preparation and analysis of soil samples does not exceed 1 hour. The detection limits in soil were 0.05 ng/g for EMPA and IPMPA, 0.02 ng/g for IBMPA and PMPA, and 1 ng/g for MPA.
U2 - 10.26896/1028-6861-2022-88-1-I-25-33
DO - 10.26896/1028-6861-2022-88-1-I-25-33
M3 - Article
SN - 1028-6861
VL - 88
SP - 25
EP - 33
JO - Industrial Laboratory. Materials Diagnostics
JF - Industrial Laboratory. Materials Diagnostics
IS - 1
ER -