Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection

D.V. Oreshkin; T.M. Baygildiev; M.F. Vokuev; A.V. Braun; I.A. Godovikov; I.V. Rybalchenko; I.A. Rodin

doi:10.1134/S1061934821130098

Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection

D.V. Oreshkin, T.M. Baygildiev, M.F. Vokuev, A.V. Braun, I.A. Godovikov, I.V. Rybalchenko, I.A. Rodin

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

© 2021, Pleiades Publishing, Ltd.Abstract: We developed a method for determining ethyl methylphosphonic, isopropyl methylphosphonic, isobutyl methylphosphonic, and pinacolyl methylphosphonic acids in human urine using gas chromatography with high-resolution mass spectrometry and preliminary derivatization with p-methoxyphenacyl bromide. All of the acids are specific hydrolysis products and biomarkers of nerve agents. Conditions of the derivatization reaction were optimized. Features and general patterns of the MS1 and MS2 spectra of derivatives acquired in electron and chemical ionization modes are revealed. The developed method achieved the limits of detection in the range from 20 to 70 ng/mL.

Original language	English
Pages (from-to)	1530-1537
Journal	Journal of Analytical Chemistry
Volume	76
Issue number	13
DOIs	https://doi.org/10.1134/S1061934821130098
Publication status	Published - 1 Dec 2021
Externally published	Yes

Funding

The study was supported by the Russian Foundation for Basic Research, project no. 18-33-20068 mol_a_ved.

Funders	Funder number
Russian Foundation for Basic Research	18-33-20068

Access to Document

10.1134/S1061934821130098

Persistent URL (handle)

Copy link address

Cite this

Oreshkin, D. V., Baygildiev, T. M., Vokuev, M. F., Braun, A. V., Godovikov, I. A., Rybalchenko, I. V., & Rodin, I. A. (2021). Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection. Journal of Analytical Chemistry, 76(13), 1530-1537. https://doi.org/10.1134/S1061934821130098

@article{6b3d3bd1e3fd4b9cb536ca92d70c7d94,

title = "Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection",

abstract = "{\textcopyright} 2021, Pleiades Publishing, Ltd.Abstract: We developed a method for determining ethyl methylphosphonic, isopropyl methylphosphonic, isobutyl methylphosphonic, and pinacolyl methylphosphonic acids in human urine using gas chromatography with high-resolution mass spectrometry and preliminary derivatization with p-methoxyphenacyl bromide. All of the acids are specific hydrolysis products and biomarkers of nerve agents. Conditions of the derivatization reaction were optimized. Features and general patterns of the MS1 and MS2 spectra of derivatives acquired in electron and chemical ionization modes are revealed. The developed method achieved the limits of detection in the range from 20 to 70 ng/mL.",

author = "D.V. Oreshkin and T.M. Baygildiev and M.F. Vokuev and A.V. Braun and I.A. Godovikov and I.V. Rybalchenko and I.A. Rodin",

year = "2021",

month = dec,

day = "1",

doi = "10.1134/S1061934821130098",

language = "English",

volume = "76",

pages = "1530--1537",

journal = "Journal of Analytical Chemistry",

issn = "1061-9348",

publisher = "Pleiades Publishing",

number = "13",

}

Oreshkin, DV, Baygildiev, TM, Vokuev, MF, Braun, AV, Godovikov, IA, Rybalchenko, IV & Rodin, IA 2021, 'Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection', Journal of Analytical Chemistry, vol. 76, no. 13, pp. 1530-1537. https://doi.org/10.1134/S1061934821130098

Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection. / Oreshkin, D.V.; Baygildiev, T.M.; Vokuev, M.F. et al.
In: Journal of Analytical Chemistry, Vol. 76, No. 13, 01.12.2021, p. 1530-1537.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection

AU - Oreshkin, D.V.

AU - Baygildiev, T.M.

AU - Vokuev, M.F.

AU - Braun, A.V.

AU - Godovikov, I.A.

AU - Rybalchenko, I.V.

AU - Rodin, I.A.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - © 2021, Pleiades Publishing, Ltd.Abstract: We developed a method for determining ethyl methylphosphonic, isopropyl methylphosphonic, isobutyl methylphosphonic, and pinacolyl methylphosphonic acids in human urine using gas chromatography with high-resolution mass spectrometry and preliminary derivatization with p-methoxyphenacyl bromide. All of the acids are specific hydrolysis products and biomarkers of nerve agents. Conditions of the derivatization reaction were optimized. Features and general patterns of the MS1 and MS2 spectra of derivatives acquired in electron and chemical ionization modes are revealed. The developed method achieved the limits of detection in the range from 20 to 70 ng/mL.

AB - © 2021, Pleiades Publishing, Ltd.Abstract: We developed a method for determining ethyl methylphosphonic, isopropyl methylphosphonic, isobutyl methylphosphonic, and pinacolyl methylphosphonic acids in human urine using gas chromatography with high-resolution mass spectrometry and preliminary derivatization with p-methoxyphenacyl bromide. All of the acids are specific hydrolysis products and biomarkers of nerve agents. Conditions of the derivatization reaction were optimized. Features and general patterns of the MS1 and MS2 spectra of derivatives acquired in electron and chemical ionization modes are revealed. The developed method achieved the limits of detection in the range from 20 to 70 ng/mL.

U2 - 10.1134/S1061934821130098

DO - 10.1134/S1061934821130098

M3 - Article

SN - 1061-9348

VL - 76

SP - 1530

EP - 1537

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

IS - 13

ER -

Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detection

Abstract

Funding

Access to Document

Persistent URL (handle)

Fingerprint

Cite this