Determination of pentachlorophenol in rabbit and human liver using liquid chromatography and gas chromatography with electron-capture detection

F. A. Maris*, G. J. de Jong, G. W. Somsen, U. A Th Brinkman, C. E. Goewie, M.P.H. van den Broek

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A method has been developed for the determination of ppb levels of pentachlorophenol (PCP) in liver by column liquid chromatography with on-line electron-capture detection (LC-ECD). The technique is compared with gas chromatography-ECD (GC-ECD) for the analysis of rabbit and human livers. Good results were generally obtained for LC-ECD down to the low-ppb range; however, in some cases problems were observed when the sample is not dissolved in the LC eluent. LC-ECD can adequately be used as a confirmation method for GC-ECD.

Original languageEnglish
Pages (from-to)1301-1308
Number of pages8
JournalChemosphere
Volume17
Issue number7
DOIs
Publication statusPublished - 1988

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