TY - JOUR
T1 - Determination of phenprocoumon in plasma and urine using at-line solid-phase extraction-capillary electrophoresis.
AU - Veraart, J.R.
AU - Gooijer, C.
AU - Lingeman, H.
AU - Velthorst, N.H.
AU - Brinkman, U.A.T.
PY - 1998
Y1 - 1998
N2 - The use of capillary electrophoresis (CE) for the analysis of biological samples is rather problematic because of the large number of interferences present in the matrix. One of the possibilities to solve such problems is to couple solid-phase extraction (SPE) at-line with CE, a technique developed in our laboratory. In this study at-line SPE-CE is performed for the determination of the anticoagulant phenprocoumon in biological fluids. Plasma samples are injected after the addition of 1 vol.% of formic acid to release the drug from binding proteins, while urine samples can be directly injected. The procedure is linear between 0.2 and 30 μg ml
AB - The use of capillary electrophoresis (CE) for the analysis of biological samples is rather problematic because of the large number of interferences present in the matrix. One of the possibilities to solve such problems is to couple solid-phase extraction (SPE) at-line with CE, a technique developed in our laboratory. In this study at-line SPE-CE is performed for the determination of the anticoagulant phenprocoumon in biological fluids. Plasma samples are injected after the addition of 1 vol.% of formic acid to release the drug from binding proteins, while urine samples can be directly injected. The procedure is linear between 0.2 and 30 μg ml
U2 - 10.1016/S0731-7085(98)00082-X
DO - 10.1016/S0731-7085(98)00082-X
M3 - Article
SN - 0731-7085
VL - 17
SP - 1161
EP - 1166
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
ER -
