TY - JOUR
T1 - Determination of the hydrolysis products of nerve agents in natural waters by liquid chromatography–mass spectrometry
AU - Rodin, I.A.
AU - Braun, A.V.
AU - Baygildiev, T.M.
AU - Anan’eva, I.A.
AU - Shpigun, O.A.
AU - Rybalchenko, I.V.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - © 2015, Pleiades Publishing, Ltd.An approach to the determination of markers of the application of four nerve agents, S-(2-diethylaminoethyl)methylphosphonothioate, S-(2-diisopropylaminoethyl)methylphosphonothioate, bis(2N,N-diethylaminoethyl)disulfide, and bis(2-N,N-diisopropylaminoethyl)disulfide, in aqueous environmental samples by high-performance liquid chromatography with tandem mass spectrometric detection (HPLC–MS2) is developed. The conditions of the mass spectrometric detection (selection of optimal pairs of ionic reactions) are optimized, and the program for the gradient elution in HPLC separation is adjusted. The proposed approach was tested in the analysis of real water bodies using the standard addition method. Good accuracy, reproducibility, and selectivity of determination were shown. It was demonstrated that the matrix components in the water samples have no interfering effect. Using the proposed approach, the detection limits of S-(2-diethylaminoethyl)methylphosphonothioate, S-(2-diisopropylaminoethyl)methylphosphonothioate, bis(2-N,N-diethylaminoethyl)disulfide, and bis(2-N,N-diisopropylaminoethyl)disulfide in water bodies, determined by HPLC–MS2, were found to be 0.0003, 0.003, 0.3, and 0.05 µg mL–1, respectively.
AB - © 2015, Pleiades Publishing, Ltd.An approach to the determination of markers of the application of four nerve agents, S-(2-diethylaminoethyl)methylphosphonothioate, S-(2-diisopropylaminoethyl)methylphosphonothioate, bis(2N,N-diethylaminoethyl)disulfide, and bis(2-N,N-diisopropylaminoethyl)disulfide, in aqueous environmental samples by high-performance liquid chromatography with tandem mass spectrometric detection (HPLC–MS2) is developed. The conditions of the mass spectrometric detection (selection of optimal pairs of ionic reactions) are optimized, and the program for the gradient elution in HPLC separation is adjusted. The proposed approach was tested in the analysis of real water bodies using the standard addition method. Good accuracy, reproducibility, and selectivity of determination were shown. It was demonstrated that the matrix components in the water samples have no interfering effect. Using the proposed approach, the detection limits of S-(2-diethylaminoethyl)methylphosphonothioate, S-(2-diisopropylaminoethyl)methylphosphonothioate, bis(2-N,N-diethylaminoethyl)disulfide, and bis(2-N,N-diisopropylaminoethyl)disulfide in water bodies, determined by HPLC–MS2, were found to be 0.0003, 0.003, 0.3, and 0.05 µg mL–1, respectively.
U2 - 10.1134/S1061934815140105
DO - 10.1134/S1061934815140105
M3 - Article
SN - 1061-9348
VL - 70
SP - 1671
EP - 1677
JO - Journal of Analytical Chemistry
JF - Journal of Analytical Chemistry
IS - 14
ER -