Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volumn injections and peak compression.

E.W.J. Hooijschuur, C.E. Kientz, U.A.T. Brinkman

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A selective, direct and relatively rapid method has been developed for the determination of thiodiglycol (TDG) in aqueous samples. TDG is the main hydrolysis product of the chemical warfare agent sulfur mustard. The method of analysis is based on the on-line coupling of reversed-phase microcolumn liquid chromatography and sulfur-selective flame photometric detection. To improve sensitivity and efficiency, peak compression by displacement was used in combination with large-volume injections. A concentration of 1% n-propanol was added to the sample to obtain the best sensitivity and efficiency after a 10 μl injection. Detection limits of 0.25 μg/ml were achieved with efficiencies of 4.10
Original languageEnglish
Pages (from-to)433-444
JournalJournal of Chromatography A
Volume849
DOIs
Publication statusPublished - 1999

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