TY - JOUR
T1 - Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volumn injections and peak compression.
AU - Hooijschuur, E.W.J.
AU - Kientz, C.E.
AU - Brinkman, U.A.T.
PY - 1999
Y1 - 1999
N2 - A selective, direct and relatively rapid method has been developed for the determination of thiodiglycol (TDG) in aqueous samples. TDG is the main hydrolysis product of the chemical warfare agent sulfur mustard. The method of analysis is based on the on-line coupling of reversed-phase microcolumn liquid chromatography and sulfur-selective flame photometric detection. To improve sensitivity and efficiency, peak compression by displacement was used in combination with large-volume injections. A concentration of 1% n-propanol was added to the sample to obtain the best sensitivity and efficiency after a 10 μl injection. Detection limits of 0.25 μg/ml were achieved with efficiencies of 4.10
AB - A selective, direct and relatively rapid method has been developed for the determination of thiodiglycol (TDG) in aqueous samples. TDG is the main hydrolysis product of the chemical warfare agent sulfur mustard. The method of analysis is based on the on-line coupling of reversed-phase microcolumn liquid chromatography and sulfur-selective flame photometric detection. To improve sensitivity and efficiency, peak compression by displacement was used in combination with large-volume injections. A concentration of 1% n-propanol was added to the sample to obtain the best sensitivity and efficiency after a 10 μl injection. Detection limits of 0.25 μg/ml were achieved with efficiencies of 4.10
U2 - 10.1016/S0021-9673(99)00612-3
DO - 10.1016/S0021-9673(99)00612-3
M3 - Article
SN - 0021-9673
VL - 849
SP - 433
EP - 444
JO - Journal of Chromatography A
JF - Journal of Chromatography A
ER -