Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volumn injections and peak compression.

E.W.J. Hooijschuur; C.E. Kientz; U.A.T. Brinkman

doi:10.1016/S0021-9673(99)00612-3

Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volumn injections and peak compression.

E.W.J. Hooijschuur, C.E. Kientz, U.A.T. Brinkman

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A selective, direct and relatively rapid method has been developed for the determination of thiodiglycol (TDG) in aqueous samples. TDG is the main hydrolysis product of the chemical warfare agent sulfur mustard. The method of analysis is based on the on-line coupling of reversed-phase microcolumn liquid chromatography and sulfur-selective flame photometric detection. To improve sensitivity and efficiency, peak compression by displacement was used in combination with large-volume injections. A concentration of 1% n-propanol was added to the sample to obtain the best sensitivity and efficiency after a 10 μl injection. Detection limits of 0.25 μg/ml were achieved with efficiencies of 4.10

Original language	English
Pages (from-to)	433-444
Journal	Journal of Chromatography A
Volume	849
DOIs	https://doi.org/10.1016/S0021-9673(99)00612-3
Publication status	Published - 1999

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title = "Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volumn injections and peak compression.",

abstract = "A selective, direct and relatively rapid method has been developed for the determination of thiodiglycol (TDG) in aqueous samples. TDG is the main hydrolysis product of the chemical warfare agent sulfur mustard. The method of analysis is based on the on-line coupling of reversed-phase microcolumn liquid chromatography and sulfur-selective flame photometric detection. To improve sensitivity and efficiency, peak compression by displacement was used in combination with large-volume injections. A concentration of 1\% n-propanol was added to the sample to obtain the best sensitivity and efficiency after a 10 μl injection. Detection limits of 0.25 μg/ml were achieved with efficiencies of 4.10",

author = "E.W.J. Hooijschuur and C.E. Kientz and U.A.T. Brinkman",

year = "1999",

doi = "10.1016/S0021-9673(99)00612-3",

language = "English",

volume = "849",

pages = "433--444",

journal = "Journal of Chromatography A",

issn = "0021-9673",

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Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volumn injections and peak compression. / Hooijschuur, E.W.J.; Kientz, C.E.; Brinkman, U.A.T.
In: Journal of Chromatography A, Vol. 849, 1999, p. 433-444.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volumn injections and peak compression.

AU - Hooijschuur, E.W.J.

AU - Kientz, C.E.

AU - Brinkman, U.A.T.

PY - 1999

Y1 - 1999

N2 - A selective, direct and relatively rapid method has been developed for the determination of thiodiglycol (TDG) in aqueous samples. TDG is the main hydrolysis product of the chemical warfare agent sulfur mustard. The method of analysis is based on the on-line coupling of reversed-phase microcolumn liquid chromatography and sulfur-selective flame photometric detection. To improve sensitivity and efficiency, peak compression by displacement was used in combination with large-volume injections. A concentration of 1% n-propanol was added to the sample to obtain the best sensitivity and efficiency after a 10 μl injection. Detection limits of 0.25 μg/ml were achieved with efficiencies of 4.10

AB - A selective, direct and relatively rapid method has been developed for the determination of thiodiglycol (TDG) in aqueous samples. TDG is the main hydrolysis product of the chemical warfare agent sulfur mustard. The method of analysis is based on the on-line coupling of reversed-phase microcolumn liquid chromatography and sulfur-selective flame photometric detection. To improve sensitivity and efficiency, peak compression by displacement was used in combination with large-volume injections. A concentration of 1% n-propanol was added to the sample to obtain the best sensitivity and efficiency after a 10 μl injection. Detection limits of 0.25 μg/ml were achieved with efficiencies of 4.10

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DO - 10.1016/S0021-9673(99)00612-3

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VL - 849

SP - 433

EP - 444

JO - Journal of Chromatography A

JF - Journal of Chromatography A

ER -

Determination of the sulfur mustard hydrolysis product thiodiglycol by microcolumn liquid chromatography coupled on-line with sulfur flame photometric detection using large-volumn injections and peak compression.

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