Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

Graham J. Kemp; Fraser Birrell; Peter D. Clegg; Daniel J. Cuthbertson; Giuseppe De Vito; Jaap H. Van Dieën; Silvia Del Din; Richard Eastell; Patrick Garnero; Katarzyna Goljanek-Whysall; Matthias Hackl; Richard Hodgson; Malcolm J. Jackson; Sue Lord; Claudia Mazzà; Anne McArdle; Eugene V. McCloskey; Marco Narici; Mandy J. Peffers; Stefano Schiaffino; John C. Mathers

doi:10.1093/ageing/afy143

Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

Graham J. Kemp
, Fraser Birrell
, Peter D. Clegg
, Daniel J. Cuthbertson
, Giuseppe De Vito
, Jaap H. Van Dieën
, Silvia Del Din
, Richard Eastell
, Patrick Garnero
, Katarzyna Goljanek-Whysall
, Matthias Hackl
, Richard Hodgson
, Malcolm J. Jackson
, Sue Lord
, Claudia Mazzà
, Anne McArdle
, Eugene V. McCloskey
, Marco Narici
, Mandy J. Peffers
, Stefano Schiaffino

John C. Mathers

Biomechanics

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function'-in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: Biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.

Original language	English
Pages (from-to)	iv1-iv19
Number of pages	19
Journal	Age and Ageing
Volume	47
Issue number	Suppl_4
DOIs	https://doi.org/10.1093/ageing/afy143
Publication status	Published - 1 Sept 2018

Bibliographical note

Published [online]: 07 September 2018

Funding

Eugene McCloskey has been in receipt of research funds from Roche Diagnostics and speaker fees from GE Lunar, Hologic, Roche, Vertec Scientific. Matthias Hackl is a shareholder and employee of TAmiRNA GmbH, which is a private company involved in the development of in vitro diagnostic tests. Richard Eastell has received grant funding and consultancy from Immunodiagnostics Systems and Roche Diagnostics. This work was supported by the Medical Research Council (MRC) and Arthritis Research UK as part of the MRC— Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) [MR/K006312/1; MR/P020941/1]. The MRC—Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing is a The authors thank Louise Jaeger-Wright, CIMA Centre Manager, Institute of Ageing and Chronic Disease, University of Liverpool for administrative support throughout the preparation of this manuscript. We also thank Dr Penny Gray, of Penny Gray and Associates, for medical writing and editorial support, which was funded by the MRC—Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) in accordance with Good Publication Practice (GPP3) guidelines (http:// www.ismpp.org/gpp3).

Funders	Funder number
Roche Diagnostics
Immunodiagnostics Systems and Roche
Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing
Centre for Ageing Research and Development in Ireland
UK Research and Innovation
Arthritis Research UK
National Institute on Aging	P01AG051442
Wellcome Trust	107471
Chartered Institute of Management Accountants	MR/K006312/1, GPP3
Medical Research Council	MR/L016354/1, MR/P020941/1
Biotechnology and Biological Sciences Research Council	BB/L021668/1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biomarkers
bone
cartilage
healthy ageing
musculoskeletal ageing
skeletal muscle

Access to Document

10.1093/ageing/afy143

Persistent URL (handle)

Persistent link

Cite this

Kemp, G. J., Birrell, F., Clegg, P. D., Cuthbertson, D. J., De Vito, G., Van Dieën, J. H., Del Din, S., Eastell, R., Garnero, P., Goljanek-Whysall, K., Hackl, M., Hodgson, R., Jackson, M. J., Lord, S., Mazzà, C., McArdle, A., McCloskey, E. V., Narici, M., Peffers, M. J., ... Mathers, J. C. (2018). Developing a toolkit for the assessment and monitoring of musculoskeletal ageing. Age and Ageing, 47(Suppl_4), iv1-iv19. https://doi.org/10.1093/ageing/afy143

@article{f0a0337f940b4de39dc5d5214a5c1f3d,

title = "Developing a toolkit for the assessment and monitoring of musculoskeletal ageing",

abstract = "The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function'-in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: Biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.",

keywords = "biomarkers, bone, cartilage, healthy ageing, musculoskeletal ageing, skeletal muscle",

author = "Kemp, \{Graham J.\} and Fraser Birrell and Clegg, \{Peter D.\} and Cuthbertson, \{Daniel J.\} and \{De Vito\}, Giuseppe and \{Van Die{\"e}n\}, \{Jaap H.\} and \{Del Din\}, Silvia and Richard Eastell and Patrick Garnero and Katarzyna Goljanek-Whysall and Matthias Hackl and Richard Hodgson and Jackson, \{Malcolm J.\} and Sue Lord and Claudia Mazz{\`a} and Anne McArdle and McCloskey, \{Eugene V.\} and Marco Narici and Peffers, \{Mandy J.\} and Stefano Schiaffino and Mathers, \{John C.\}",

note = "Published [online]: 07 September 2018",

year = "2018",

month = sep,

day = "1",

doi = "10.1093/ageing/afy143",

language = "English",

volume = "47",

pages = "iv1--iv19",

journal = "Age and Ageing",

issn = "0002-0729",

publisher = "Oxford University Press",

number = "Suppl\_4",

}

Kemp, GJ, Birrell, F, Clegg, PD, Cuthbertson, DJ, De Vito, G, Van Dieën, JH, Del Din, S, Eastell, R, Garnero, P, Goljanek-Whysall, K, Hackl, M, Hodgson, R, Jackson, MJ, Lord, S, Mazzà, C, McArdle, A, McCloskey, EV, Narici, M, Peffers, MJ, Schiaffino, S & Mathers, JC 2018, 'Developing a toolkit for the assessment and monitoring of musculoskeletal ageing', Age and Ageing, vol. 47, no. Suppl_4, pp. iv1-iv19. https://doi.org/10.1093/ageing/afy143

TY - JOUR

T1 - Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

AU - Kemp, Graham J.

AU - Birrell, Fraser

AU - Clegg, Peter D.

AU - Cuthbertson, Daniel J.

AU - De Vito, Giuseppe

AU - Van Dieën, Jaap H.

AU - Del Din, Silvia

AU - Eastell, Richard

AU - Garnero, Patrick

AU - Goljanek-Whysall, Katarzyna

AU - Hackl, Matthias

AU - Hodgson, Richard

AU - Jackson, Malcolm J.

AU - Lord, Sue

AU - Mazzà, Claudia

AU - McArdle, Anne

AU - McCloskey, Eugene V.

AU - Narici, Marco

AU - Peffers, Mandy J.

AU - Schiaffino, Stefano

AU - Mathers, John C.

N1 - Published [online]: 07 September 2018

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function'-in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: Biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.

AB - The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function'-in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: Biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.

KW - biomarkers

KW - bone

KW - cartilage

KW - healthy ageing

KW - musculoskeletal ageing

KW - skeletal muscle

UR - https://www.scopus.com/pages/publications/85054154795

UR - https://www.scopus.com/pages/publications/85054154795#tab=citedBy

U2 - 10.1093/ageing/afy143

DO - 10.1093/ageing/afy143

M3 - Review article

C2 - 30203052

SN - 0002-0729

VL - 47

SP - iv1-iv19

JO - Age and Ageing

JF - Age and Ageing

IS - Suppl_4

ER -

Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this