Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase

J. Reinen, E. Vriese, H.R. Glatt, N.P.E. Vermeulen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Human estrogen sulfotransferase (SULT1E1) is involved in the regulation of 17β-estradiol responsiveness and is believed to protect peripheral tissues from excessive estrogenic effects. Several assays already have been developed to investigate the inhibitory effect of endocrine-disrupting compounds (EDCs) on SULT1E1. However, most of these assays make use of the radiolabeled cofactor [
Original languageEnglish
Pages (from-to)85-92
JournalAnalytical Biochemistry
Volume357
Issue number1
DOIs
Publication statusPublished - 2006

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