Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach

Kaisa Koivunen; Emiel O Hoogendijk; Laura A Schaap; Martijn Huisman; Martijn W Heymans; Natasja M van Schoor

doi:10.1007/s40520-023-02366-2

Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach

Kaisa Koivunen
, Emiel O Hoogendijk
, Laura A Schaap
, Martijn Huisman
, Martijn W Heymans
, Natasja M van Schoor

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Intrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person's IC is determined by its domain-specific indicators suggesting a formative measurement model.

AIMS: To develop an IC score applying a formative approach and assess its validity.

METHODS: The study sample (n = 1908) consisted of 57-88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year functional decline as an outcome. An IC score (range 0-100) was constructed for each participant. We examined the known-groups' validity of the IC score by comparing groups based on age and number of chronic diseases. The criterion validity of the IC score was assessed with 6-year functional decline and 10-year mortality as outcomes.

RESULTS: The constructed IC score included seven indicators covering all five domains of the construct. The mean IC score was 66.7 (SD 10.3). The scores were higher among younger participants and those who had lower number of chronic diseases. After adjustment for sociodemographic indicators, chronic diseases, and BMI, a one-point higher IC score was associated with a 7% decreased risk for 6-year functional decline and a 2% decreased risk for 10-year mortality.

CONCLUSIONS: The developed IC score demonstrated discriminative ability according to age and health status and is associated with subsequent functional decline and mortality.

Original language	English
Pages (from-to)	815-825
Number of pages	11
Journal	Aging Clinical and Experimental Research
Volume	35
Issue number	4
Early online date	23 Feb 2023
DOIs	https://doi.org/10.1007/s40520-023-02366-2
Publication status	Published - Apr 2023

Bibliographical note

Funding

Open Access funding provided by University of Jyväskylä (JYU). The Longitudinal Aging Study Amsterdam is supported by a grant from the Netherlands Ministry of Health Welfare and Sports, Directorate of Long-Term Care. This work was also supported by the European Research Council ERC Advanced Grant [693045 to Taina Rantanen, JYU], the Academy of Finland [310526 to Taina Rantanen, JYU], and the University of Jyväskylä (JYU) Finland. The content of this manuscript does not reflect the official opinion of the European Union. Responsibility for the information and views expressed in the manuscript lies entirely with the authors.

Funders	Funder number
European Research Council
Netherlands Ministry of Health Welfare and Sports, Directorate of Long-Term Care
Jyväskylän Yliopisto
Research Council of Finland	310526
Horizon 2020 Framework Programme	693045

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 16 Peace, Justice and Strong Institutions

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title = "Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach",

abstract = "BACKGROUND: Intrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person's IC is determined by its domain-specific indicators suggesting a formative measurement model.AIMS: To develop an IC score applying a formative approach and assess its validity.METHODS: The study sample (n = 1908) consisted of 57-88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year functional decline as an outcome. An IC score (range 0-100) was constructed for each participant. We examined the known-groups' validity of the IC score by comparing groups based on age and number of chronic diseases. The criterion validity of the IC score was assessed with 6-year functional decline and 10-year mortality as outcomes.RESULTS: The constructed IC score included seven indicators covering all five domains of the construct. The mean IC score was 66.7 (SD 10.3). The scores were higher among younger participants and those who had lower number of chronic diseases. After adjustment for sociodemographic indicators, chronic diseases, and BMI, a one-point higher IC score was associated with a 7\% decreased risk for 6-year functional decline and a 2\% decreased risk for 10-year mortality.CONCLUSIONS: The developed IC score demonstrated discriminative ability according to age and health status and is associated with subsequent functional decline and mortality.",

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AU - Huisman, Martijn

AU - Heymans, Martijn W

AU - van Schoor, Natasja M

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Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach

Abstract

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UN SDGs

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