Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices

M. Eggink; S. Charret; M. Wijtmans; H. Lingeman; J. Kool; W.M. Niessen; H. Irth

doi:10.1016/j.jchromb.2009.09.043

Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices

M. Eggink, S. Charret, M. Wijtmans, H. Lingeman, J. Kool, W.M. Niessen, H. Irth

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

This paper focuses on the development and optimization of an on-line weak-cation exchange SPE (WCXE) coupled to gradient HPLC with tandem MS detection. The system enables the selective purification and re-concentration of the in-vial derivatized aldehydes from plasma and urine samples. Aldehydes are important as biomarkers for oxidative stress. Using a derivatization cocktail consisting of 4-(2-(trimethylammonio)ethoxy)benzenaminium dibromide (4-APC) and NaBH

Original language	English
Pages (from-to)	3937-45
Journal	Journal of Chromatography B
Volume	877
Issue number	31
DOIs	https://doi.org/10.1016/j.jchromb.2009.09.043
Publication status	Published - 2009

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title = "Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices",

abstract = "This paper focuses on the development and optimization of an on-line weak-cation exchange SPE (WCXE) coupled to gradient HPLC with tandem MS detection. The system enables the selective purification and re-concentration of the in-vial derivatized aldehydes from plasma and urine samples. Aldehydes are important as biomarkers for oxidative stress. Using a derivatization cocktail consisting of 4-(2-(trimethylammonio)ethoxy)benzenaminium dibromide (4-APC) and NaBH",

author = "M. Eggink and S. Charret and M. Wijtmans and H. Lingeman and J. Kool and W.M. Niessen and H. Irth",

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doi = "10.1016/j.jchromb.2009.09.043",

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T1 - Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices

AU - Eggink, M.

AU - Charret, S.

AU - Wijtmans, M.

AU - Lingeman, H.

AU - Kool, J.

AU - Niessen, W.M.

AU - Irth, H.

PY - 2009

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AB - This paper focuses on the development and optimization of an on-line weak-cation exchange SPE (WCXE) coupled to gradient HPLC with tandem MS detection. The system enables the selective purification and re-concentration of the in-vial derivatized aldehydes from plasma and urine samples. Aldehydes are important as biomarkers for oxidative stress. Using a derivatization cocktail consisting of 4-(2-(trimethylammonio)ethoxy)benzenaminium dibromide (4-APC) and NaBH

U2 - 10.1016/j.jchromb.2009.09.043

DO - 10.1016/j.jchromb.2009.09.043

M3 - Article

SN - 1570-0232

VL - 877

SP - 3937

EP - 3945

JO - Journal of Chromatography B

JF - Journal of Chromatography B

IS - 31

ER -

Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices

Abstract

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