Developmental co‐occurrence of psychopathology dimensions in childhood

Andrea G. Allegrini; T.C.E.M. van Beijsterveldt; Dorret I. Boomsma; Kaili Rimfeld; Jean‐Baptiste Pingault; Robert Plomin; Meike Bartels; Michel G. Nivard

doi:10.1002/jcv2.12100

Developmental co‐occurrence of psychopathology dimensions in childhood

Andrea G. Allegrini
, T.C.E.M. van Beijsterveldt
, Dorret I. Boomsma
, Kaili Rimfeld
, Jean‐Baptiste Pingault
, Robert Plomin
, Meike Bartels
, Michel G. Nivard

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background
Comorbidity between psychopathologies may be attributed to genetic and environmental differences between people as well as causal processes within individuals, where one pathology increases risk for another. Disentangling between-person (co)variance from within-person processes of psychopathology dimensions across childhood may shed light on developmental causes of comorbid mental health problems. Here, we aim to determine whether and to what extent directional relationships between psychopathology dimensions within-person, and between individuals within families, play a role in comorbidity.

Methods
We conducted random intercepts cross-lagged panel model (RI-CLPM) analyses to unravel the longitudinal co-occurrence of child psychopathology dimensions, jointly estimating between-person and within-person processes from childhood to early adolescence (age 7–12). We further developed an extension of the model to estimate sibling effects within-family (wf-RI-CLPM). Analyses were separately conducted in two large population-based cohorts, TEDS and NTR, including parent-rated measures of child problem behaviours based on the SDQ and CBCL scales respectively.

Results
We found evidence for strong between-person effects underlying the positive intercorrelation between problem behaviours across time. Beyond these time-varying within-person processes accounted for an increasing amount of trait variance, within- and cross-trait, overtime in both cohorts. Lastly, by accommodating family level data, we found evidence for reciprocal directional influences within sib-pairs longitudinally.

Conclusions
Our results indicate that within-person processes partly explain the co-occurrence of psychopathology dimensions across childhood, and within sib-pairs. Analyses provided substantive results on developmental processes underlying comorbidity in behavioural problems. Future studies should consider different developmental timeframes to shed more light on the processes contributing to developmental comorbidity.

Original language	English
Article number	e12100
Pages (from-to)	1-13
Number of pages	13
Journal	JCPP Advances
Volume	2
Issue number	3
Early online date	5 Sept 2022
DOIs	https://doi.org/10.1002/jcv2.12100
Publication status	Published - Sept 2022

Funding

This project has received funding from the European Union's Horizon 2020 research and innovation programme, Marie Sklodowska Curie Actions (MSCA-ITN-2016) Innovative Training Networks (CAPICE grant 721567). MB is funded by an European Research Council Consolidator grant (WELL-BEING grant 771057). MGN is supported by ZonMW grants 849200011and 531003014 from The Netherlands Organisation for Health Research and Development, a VENI grant awarded by NWO (VI.Veni.191G.030), NIH grant R01MH120219 and he is a Jacobs foundation research fellow. We gratefully acknowledge the on-going contribution of the participants in the Twins Early Development Study (TEDS) and their families. TEDS is supported by a programme Grant to R.P. from the UK Medical Research Council (Grant Nos. MR/V012878/1 and previously MR/M021475/1), with additional support from the US National Institutes of Health (Grant No. AG046938). The research leading to these results has also received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007\u20132013)/grant agreement n\u00B0 602768). K.R. is supported by a Sir Henry Welcome Postdoctoral Fellowship. Funding was obtained from multiple grants from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW): Genetic influences on stability and change in psychopathology from childhood to young adulthood (ZonMw 912-10-020); Twin family database for behavior genomics studies (NWO 480-04-004); Genetic and Family Influences on Adolescent. Psychopathology and Wellness (NWO 463-06-001); Geno-type/phenotype database for behavior genetic and genetic epidemiological studies (ZonMw Middelgroot 911-09-032); \u201CWhy some children thrive\u201D (OCW_Gravity program -NWO-024.001.003), Netherlands Twin Registry Repository: researching the interplay between genome and environment (NWO-Groot 480-15-001/674); BBMRI \u2013NL (184.021.007 and 184.033.111): Biobanking and Biomolecular Resources Research Infrastructure; Spinozapremie (NWO- 56-464-14192) and KNAW Academy Professor Award (PAH/6635) to DIB; Amsterdam Reproduction and Development (AR&D) and Amsterdam Public Health (APH); the European Science Council (ERC) Genetics of Mental Illness (ERC Advanced, 230374); NIH: Rutgers University Cell and DNA Repository cooperative agreement (NIMH U24 MH068457-06); Developmental Study of Attention Problems in Young Twins (NIMH, RO1 MH58799-03); Grand Opportunity grant Developmental trajectories of psychopathology (NIMH 1RC2 MH089995) and the Avera Institute for Human Genetics. This project has received funding from the European Union's Horizon 2020 research and innovation programme, Marie Sklodowska Curie Actions (MSCA\u2010ITN\u20102016) Innovative Training Networks (CAPICE grant 721567). MB is funded by an European Research Council Consolidator grant (WELL\u2010BEING grant 771057). MGN is supported by ZonMW grants 849200011and 531003014 from The Netherlands Organisation for Health Research and Development, a VENI grant awarded by NWO (VI.Veni.191G.030), NIH grant R01MH120219 and he is a Jacobs foundation research fellow. We gratefully acknowledge the on\u2010going contribution of the participants in the Twins Early Development Study (TEDS) and their families. TEDS is supported by a programme Grant to R.P. from the UK Medical Research Council (Grant Nos. MR/V012878/1 and previously MR/M021475/1), with additional support from the US National Institutes of Health (Grant No. AG046938). The research leading to these results has also received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007\u20132013)/grant agreement n\u00B0 602768). K.R. is supported by a Sir Henry Welcome Postdoctoral Fellowship. Funding was obtained from multiple grants from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW): Genetic influences on stability and change in psychopathology from childhood to young adulthood (ZonMw 912\u201010\u2010020); Twin family database for behavior genomics studies (NWO 480\u201004\u2010004); Genetic and Family Influences on Adolescent. Psychopathology and Wellness (NWO 463\u201006\u2010001); Geno\u2010type/phenotype database for behavior genetic and genetic epidemiological studies (ZonMw Middelgroot 911\u201009\u2010032); \u201CWhy some children thrive\u201D (OCW_Gravity program \u2010NWO\u2010024.001.003), Netherlands Twin Registry Repository: researching the interplay between genome and environment (NWO\u2010Groot 480\u201015\u2010001/674); BBMRI \u2013NL (184.021.007 and 184.033.111): Biobanking and Biomolecular Resources Research Infrastructure; Spinozapremie (NWO\u2010 56\u2010464\u201014192) and KNAW Academy Professor Award (PAH/6635) to DIB; Amsterdam Reproduction and Development (AR&D) and Amsterdam Public Health (APH); the European Science Council (ERC) Genetics of Mental Illness (ERC Advanced, 230374); NIH: Rutgers University Cell and DNA Repository cooperative agreement (NIMH U24 MH068457\u201006); Developmental Study of Attention Problems in Young Twins (NIMH, RO1 MH58799\u201003); Grand Opportunity grant Developmental trajectories of psychopathology (NIMH 1RC2 MH089995) and the Avera Institute for Human Genetics.

Funders	Funder number
Sir Henry Welcome Postdoctoral Fellowship
European Union's Seventh Framework Programme
European Science Council
Genetics of Mental Illness
Avera Institute for Human Genetics
European Commission
NWO-Groot
European Research Council
Horizon 2020
UK Research and Innovation
Medical Research Council	MR/V012878/1, MR/M021475/1
H2020 Marie Skłodowska-Curie Actions	MSCA‐ITN‐2016, 721567
Seventh Framework Programme	602768
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	480-04-004, VI.Veni.191G.030
National Institute of Mental Health	1RC2 MH089995, RO1 MH58799‐03, U24 MH068457‐06
National Institutes of Health	R01MH120219, AG046938
Horizon 2020 Framework Programme	230374, 771057
ZonMw	480‐15‐001/674, 463‐06‐001, 849200011and 531003014, NWO-024.001.003, Middelgroot 911-09-032, 911‐09‐032, NWO 480-04-004, 912‐10‐020
Koninklijke Nederlandse Akademie van Wetenschappen	PAH/6635
BBMRI	184.033.111, NWO- 56-464-14192, 56‐464‐14192, 184.021.007

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10.1002/jcv2.12100

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@article{91f9a18c4b4542f3a98700ddb791149f,

title = "Developmental co‐occurrence of psychopathology dimensions in childhood",

abstract = "Background Comorbidity between psychopathologies may be attributed to genetic and environmental differences between people as well as causal processes within individuals, where one pathology increases risk for another. Disentangling between-person (co)variance from within-person processes of psychopathology dimensions across childhood may shed light on developmental causes of comorbid mental health problems. Here, we aim to determine whether and to what extent directional relationships between psychopathology dimensions within-person, and between individuals within families, play a role in comorbidity. Methods We conducted random intercepts cross-lagged panel model (RI-CLPM) analyses to unravel the longitudinal co-occurrence of child psychopathology dimensions, jointly estimating between-person and within-person processes from childhood to early adolescence (age 7–12). We further developed an extension of the model to estimate sibling effects within-family (wf-RI-CLPM). Analyses were separately conducted in two large population-based cohorts, TEDS and NTR, including parent-rated measures of child problem behaviours based on the SDQ and CBCL scales respectively. Results We found evidence for strong between-person effects underlying the positive intercorrelation between problem behaviours across time. Beyond these time-varying within-person processes accounted for an increasing amount of trait variance, within- and cross-trait, overtime in both cohorts. Lastly, by accommodating family level data, we found evidence for reciprocal directional influences within sib-pairs longitudinally. Conclusions Our results indicate that within-person processes partly explain the co-occurrence of psychopathology dimensions across childhood, and within sib-pairs. Analyses provided substantive results on developmental processes underlying comorbidity in behavioural problems. Future studies should consider different developmental timeframes to shed more light on the processes contributing to developmental comorbidity. ",

author = "Allegrini, \{Andrea G.\} and \{van Beijsterveldt\}, T.C.E.M. and Boomsma, \{Dorret I.\} and Kaili Rimfeld and Jean‐Baptiste Pingault and Robert Plomin and Meike Bartels and Nivard, \{Michel G.\}",

year = "2022",

month = sep,

doi = "10.1002/jcv2.12100",

language = "English",

volume = "2",

pages = "1--13",

journal = "JCPP Advances",

issn = "2692-9384",

publisher = "John Wiley and Sons Ltd",

number = "3",

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T1 - Developmental co‐occurrence of psychopathology dimensions in childhood

AU - Allegrini, Andrea G.

AU - van Beijsterveldt, T.C.E.M.

AU - Boomsma, Dorret I.

AU - Rimfeld, Kaili

AU - Pingault, Jean‐Baptiste

AU - Plomin, Robert

AU - Bartels, Meike

AU - Nivard, Michel G.

PY - 2022/9

Y1 - 2022/9

N2 - Background Comorbidity between psychopathologies may be attributed to genetic and environmental differences between people as well as causal processes within individuals, where one pathology increases risk for another. Disentangling between-person (co)variance from within-person processes of psychopathology dimensions across childhood may shed light on developmental causes of comorbid mental health problems. Here, we aim to determine whether and to what extent directional relationships between psychopathology dimensions within-person, and between individuals within families, play a role in comorbidity. Methods We conducted random intercepts cross-lagged panel model (RI-CLPM) analyses to unravel the longitudinal co-occurrence of child psychopathology dimensions, jointly estimating between-person and within-person processes from childhood to early adolescence (age 7–12). We further developed an extension of the model to estimate sibling effects within-family (wf-RI-CLPM). Analyses were separately conducted in two large population-based cohorts, TEDS and NTR, including parent-rated measures of child problem behaviours based on the SDQ and CBCL scales respectively. Results We found evidence for strong between-person effects underlying the positive intercorrelation between problem behaviours across time. Beyond these time-varying within-person processes accounted for an increasing amount of trait variance, within- and cross-trait, overtime in both cohorts. Lastly, by accommodating family level data, we found evidence for reciprocal directional influences within sib-pairs longitudinally. Conclusions Our results indicate that within-person processes partly explain the co-occurrence of psychopathology dimensions across childhood, and within sib-pairs. Analyses provided substantive results on developmental processes underlying comorbidity in behavioural problems. Future studies should consider different developmental timeframes to shed more light on the processes contributing to developmental comorbidity.

AB - Background Comorbidity between psychopathologies may be attributed to genetic and environmental differences between people as well as causal processes within individuals, where one pathology increases risk for another. Disentangling between-person (co)variance from within-person processes of psychopathology dimensions across childhood may shed light on developmental causes of comorbid mental health problems. Here, we aim to determine whether and to what extent directional relationships between psychopathology dimensions within-person, and between individuals within families, play a role in comorbidity. Methods We conducted random intercepts cross-lagged panel model (RI-CLPM) analyses to unravel the longitudinal co-occurrence of child psychopathology dimensions, jointly estimating between-person and within-person processes from childhood to early adolescence (age 7–12). We further developed an extension of the model to estimate sibling effects within-family (wf-RI-CLPM). Analyses were separately conducted in two large population-based cohorts, TEDS and NTR, including parent-rated measures of child problem behaviours based on the SDQ and CBCL scales respectively. Results We found evidence for strong between-person effects underlying the positive intercorrelation between problem behaviours across time. Beyond these time-varying within-person processes accounted for an increasing amount of trait variance, within- and cross-trait, overtime in both cohorts. Lastly, by accommodating family level data, we found evidence for reciprocal directional influences within sib-pairs longitudinally. Conclusions Our results indicate that within-person processes partly explain the co-occurrence of psychopathology dimensions across childhood, and within sib-pairs. Analyses provided substantive results on developmental processes underlying comorbidity in behavioural problems. Future studies should consider different developmental timeframes to shed more light on the processes contributing to developmental comorbidity.

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DO - 10.1002/jcv2.12100

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JO - JCPP Advances

JF - JCPP Advances

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M1 - e12100

ER -

Developmental co‐occurrence of psychopathology dimensions in childhood

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