Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population

Y.A.L. Pijnenburg; J.L. Mulder; J.C. van Swieten; B.M.J. Uitdehaag; M. Stevens; P. Scheltens; C. Jonker

doi:10.1159/000112852

Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population

Y.A.L. Pijnenburg, J.L. Mulder, J.C. van Swieten, B.M.J. Uitdehaag, M. Stevens, P. Scheltens, C. Jonker

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Abstract

Background/Aims: The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population. Methods: The 5 core diagnostic criteria for FTD were operationalised in an informant-based written questionnaire. For a diagnosis of FTD the total clinical picture was weighted with findings on additional investigations and possible exclusion criteria, with follow-up of at least 1 year. Results: The operationalised core criteria for FTD had a sensitivity of 79% (95% CI = 57-92) and a specificity of 90% (95% CI = 85-94). Conclusion: The core diagnostic criteria for FTD applied in a caregiver questionnaire have good diagnostic accuracy among subjects without advanced dementia attending a memory clinic. This stresses the importance of the informant-based history in the differential diagnosis of dementia. Copyright © 2008 S. Karger AG.

Original language	English
Pages (from-to)	157-164
Journal	Dementia and Geriatric Cognitive Disorders
Volume	25
Issue number	2
DOIs	https://doi.org/10.1159/000112852
Publication status	Published - 2008

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title = "Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population",

abstract = "Background/Aims: The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population. Methods: The 5 core diagnostic criteria for FTD were operationalised in an informant-based written questionnaire. For a diagnosis of FTD the total clinical picture was weighted with findings on additional investigations and possible exclusion criteria, with follow-up of at least 1 year. Results: The operationalised core criteria for FTD had a sensitivity of 79% (95% CI = 57-92) and a specificity of 90% (95% CI = 85-94). Conclusion: The core diagnostic criteria for FTD applied in a caregiver questionnaire have good diagnostic accuracy among subjects without advanced dementia attending a memory clinic. This stresses the importance of the informant-based history in the differential diagnosis of dementia. Copyright {\textcopyright} 2008 S. Karger AG.",

author = "Y.A.L. Pijnenburg and J.L. Mulder and {van Swieten}, J.C. and B.M.J. Uitdehaag and M. Stevens and P. Scheltens and C. Jonker",

year = "2008",

doi = "10.1159/000112852",

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journal = "Dementia and Geriatric Cognitive Disorders",

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publisher = "S. Karger AG",

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TY - JOUR

T1 - Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population

AU - Pijnenburg, Y.A.L.

AU - Mulder, J.L.

AU - van Swieten, J.C.

AU - Uitdehaag, B.M.J.

AU - Stevens, M.

AU - Scheltens, P.

AU - Jonker, C.

PY - 2008

Y1 - 2008

N2 - Background/Aims: The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population. Methods: The 5 core diagnostic criteria for FTD were operationalised in an informant-based written questionnaire. For a diagnosis of FTD the total clinical picture was weighted with findings on additional investigations and possible exclusion criteria, with follow-up of at least 1 year. Results: The operationalised core criteria for FTD had a sensitivity of 79% (95% CI = 57-92) and a specificity of 90% (95% CI = 85-94). Conclusion: The core diagnostic criteria for FTD applied in a caregiver questionnaire have good diagnostic accuracy among subjects without advanced dementia attending a memory clinic. This stresses the importance of the informant-based history in the differential diagnosis of dementia. Copyright © 2008 S. Karger AG.

AB - Background/Aims: The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population. Methods: The 5 core diagnostic criteria for FTD were operationalised in an informant-based written questionnaire. For a diagnosis of FTD the total clinical picture was weighted with findings on additional investigations and possible exclusion criteria, with follow-up of at least 1 year. Results: The operationalised core criteria for FTD had a sensitivity of 79% (95% CI = 57-92) and a specificity of 90% (95% CI = 85-94). Conclusion: The core diagnostic criteria for FTD applied in a caregiver questionnaire have good diagnostic accuracy among subjects without advanced dementia attending a memory clinic. This stresses the importance of the informant-based history in the differential diagnosis of dementia. Copyright © 2008 S. Karger AG.

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DO - 10.1159/000112852

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JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 2

ER -

Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population

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