Diagnostic capability of 3d peripapillary retinal volume for glaucoma using optical coherence tomography customized software

Yingna Liu, Firas Jassim, Boy Braaf, Ziad Khoueir, Linda Yi Chieh Poon, Geulah S. Ben-David, Georgia Papadogeorgou, Edem Tsikata, Huseyin Simavli, Christian Que, Ramon Lee, Eric Shieh, Benjamin J. Vakoc, Brett E. Bouma, Johannes F. De Boer, Teresa C. Chen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Précis:The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts.Purpose:To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma.Patients and Methods:A retrospective cross-sectional analysis was conducted. A total of 180 subjects (113 open-angle glaucoma, 67 normal participants) had spectral domain optical coherence tomography volume scans and RNFL thickness measurements. Peripapillary RV values were calculated using a custom-designed program with 4 circumpapillary annuli (CA): CA1 had circle diameters of 2.5 and 3.5 mm; CA2, 3 and 4 mm; CA3, 3.5 and 4.5 mm; and CA4, 4 and 5 mm. Area under the receiver operating characteristic curves were calculated for global, quadrant, and octant regions for RV (CA1 to CA4) and RNFL thickness. Pair-wise comparisons were conducted. Artifacts rates were determined.Results:Mean age was 62.7±15.4 years, and 47.8% (86/180) were male. Among RV measurements, best diagnostic performances were for the smallest 2 annuli for inferior RV (CA1: 0.964, CA2: 0.955). Of the 4 annuli, CA1 had the highest diagnostic performance. Of specific regions, the inferior RV quadrant had the highest performance across CA1 to CA4. Peripapillary RV had similar diagnostic capability compared with RNFL thickness (P>0.05). The artifact rate per B-scan for RV was 6.0%, which was significantly lower compared with 2-dimensional RNFL thickness in the same patient population (32.2%, P<0.0001).Conclusions:The diagnostic capability of RV is similar to RNFL thickness for perimetric open-angle glaucoma, but RV had fewer artifacts compared with RNFL thickness.

Original languageEnglish
Pages (from-to)708-717
Number of pages10
JournalJournal of Glaucoma
Volume28
Issue number8
DOIs
Publication statusPublished - Aug 2019

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Optical Coherence Tomography
Nerve Fibers
Glaucoma
Software
Artifacts
Open Angle Glaucoma
ROC Curve
Cross-Sectional Studies
Population

Keywords

  • open-angle glaucoma
  • optical coherence tomography
  • retinal volume

Cite this

Liu, Yingna ; Jassim, Firas ; Braaf, Boy ; Khoueir, Ziad ; Poon, Linda Yi Chieh ; Ben-David, Geulah S. ; Papadogeorgou, Georgia ; Tsikata, Edem ; Simavli, Huseyin ; Que, Christian ; Lee, Ramon ; Shieh, Eric ; Vakoc, Benjamin J. ; Bouma, Brett E. ; De Boer, Johannes F. ; Chen, Teresa C. / Diagnostic capability of 3d peripapillary retinal volume for glaucoma using optical coherence tomography customized software. In: Journal of Glaucoma. 2019 ; Vol. 28, No. 8. pp. 708-717.
@article{666e93e4a3dc4d1780b0933d24ebb879,
title = "Diagnostic capability of 3d peripapillary retinal volume for glaucoma using optical coherence tomography customized software",
abstract = "Pr{\'e}cis:The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts.Purpose:To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma.Patients and Methods:A retrospective cross-sectional analysis was conducted. A total of 180 subjects (113 open-angle glaucoma, 67 normal participants) had spectral domain optical coherence tomography volume scans and RNFL thickness measurements. Peripapillary RV values were calculated using a custom-designed program with 4 circumpapillary annuli (CA): CA1 had circle diameters of 2.5 and 3.5 mm; CA2, 3 and 4 mm; CA3, 3.5 and 4.5 mm; and CA4, 4 and 5 mm. Area under the receiver operating characteristic curves were calculated for global, quadrant, and octant regions for RV (CA1 to CA4) and RNFL thickness. Pair-wise comparisons were conducted. Artifacts rates were determined.Results:Mean age was 62.7±15.4 years, and 47.8{\%} (86/180) were male. Among RV measurements, best diagnostic performances were for the smallest 2 annuli for inferior RV (CA1: 0.964, CA2: 0.955). Of the 4 annuli, CA1 had the highest diagnostic performance. Of specific regions, the inferior RV quadrant had the highest performance across CA1 to CA4. Peripapillary RV had similar diagnostic capability compared with RNFL thickness (P>0.05). The artifact rate per B-scan for RV was 6.0{\%}, which was significantly lower compared with 2-dimensional RNFL thickness in the same patient population (32.2{\%}, P<0.0001).Conclusions:The diagnostic capability of RV is similar to RNFL thickness for perimetric open-angle glaucoma, but RV had fewer artifacts compared with RNFL thickness.",
keywords = "open-angle glaucoma, optical coherence tomography, retinal volume",
author = "Yingna Liu and Firas Jassim and Boy Braaf and Ziad Khoueir and Poon, {Linda Yi Chieh} and Ben-David, {Geulah S.} and Georgia Papadogeorgou and Edem Tsikata and Huseyin Simavli and Christian Que and Ramon Lee and Eric Shieh and Vakoc, {Benjamin J.} and Bouma, {Brett E.} and {De Boer}, {Johannes F.} and Chen, {Teresa C.}",
year = "2019",
month = "8",
doi = "10.1097/IJG.0000000000001291",
language = "English",
volume = "28",
pages = "708--717",
journal = "Journal of Glaucoma",
issn = "1057-0829",
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number = "8",

}

Liu, Y, Jassim, F, Braaf, B, Khoueir, Z, Poon, LYC, Ben-David, GS, Papadogeorgou, G, Tsikata, E, Simavli, H, Que, C, Lee, R, Shieh, E, Vakoc, BJ, Bouma, BE, De Boer, JF & Chen, TC 2019, 'Diagnostic capability of 3d peripapillary retinal volume for glaucoma using optical coherence tomography customized software' Journal of Glaucoma, vol. 28, no. 8, pp. 708-717. https://doi.org/10.1097/IJG.0000000000001291

Diagnostic capability of 3d peripapillary retinal volume for glaucoma using optical coherence tomography customized software. / Liu, Yingna; Jassim, Firas; Braaf, Boy; Khoueir, Ziad; Poon, Linda Yi Chieh; Ben-David, Geulah S.; Papadogeorgou, Georgia; Tsikata, Edem; Simavli, Huseyin; Que, Christian; Lee, Ramon; Shieh, Eric; Vakoc, Benjamin J.; Bouma, Brett E.; De Boer, Johannes F.; Chen, Teresa C.

In: Journal of Glaucoma, Vol. 28, No. 8, 08.2019, p. 708-717.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Diagnostic capability of 3d peripapillary retinal volume for glaucoma using optical coherence tomography customized software

AU - Liu, Yingna

AU - Jassim, Firas

AU - Braaf, Boy

AU - Khoueir, Ziad

AU - Poon, Linda Yi Chieh

AU - Ben-David, Geulah S.

AU - Papadogeorgou, Georgia

AU - Tsikata, Edem

AU - Simavli, Huseyin

AU - Que, Christian

AU - Lee, Ramon

AU - Shieh, Eric

AU - Vakoc, Benjamin J.

AU - Bouma, Brett E.

AU - De Boer, Johannes F.

AU - Chen, Teresa C.

PY - 2019/8

Y1 - 2019/8

N2 - Précis:The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts.Purpose:To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma.Patients and Methods:A retrospective cross-sectional analysis was conducted. A total of 180 subjects (113 open-angle glaucoma, 67 normal participants) had spectral domain optical coherence tomography volume scans and RNFL thickness measurements. Peripapillary RV values were calculated using a custom-designed program with 4 circumpapillary annuli (CA): CA1 had circle diameters of 2.5 and 3.5 mm; CA2, 3 and 4 mm; CA3, 3.5 and 4.5 mm; and CA4, 4 and 5 mm. Area under the receiver operating characteristic curves were calculated for global, quadrant, and octant regions for RV (CA1 to CA4) and RNFL thickness. Pair-wise comparisons were conducted. Artifacts rates were determined.Results:Mean age was 62.7±15.4 years, and 47.8% (86/180) were male. Among RV measurements, best diagnostic performances were for the smallest 2 annuli for inferior RV (CA1: 0.964, CA2: 0.955). Of the 4 annuli, CA1 had the highest diagnostic performance. Of specific regions, the inferior RV quadrant had the highest performance across CA1 to CA4. Peripapillary RV had similar diagnostic capability compared with RNFL thickness (P>0.05). The artifact rate per B-scan for RV was 6.0%, which was significantly lower compared with 2-dimensional RNFL thickness in the same patient population (32.2%, P<0.0001).Conclusions:The diagnostic capability of RV is similar to RNFL thickness for perimetric open-angle glaucoma, but RV had fewer artifacts compared with RNFL thickness.

AB - Précis:The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts.Purpose:To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma.Patients and Methods:A retrospective cross-sectional analysis was conducted. A total of 180 subjects (113 open-angle glaucoma, 67 normal participants) had spectral domain optical coherence tomography volume scans and RNFL thickness measurements. Peripapillary RV values were calculated using a custom-designed program with 4 circumpapillary annuli (CA): CA1 had circle diameters of 2.5 and 3.5 mm; CA2, 3 and 4 mm; CA3, 3.5 and 4.5 mm; and CA4, 4 and 5 mm. Area under the receiver operating characteristic curves were calculated for global, quadrant, and octant regions for RV (CA1 to CA4) and RNFL thickness. Pair-wise comparisons were conducted. Artifacts rates were determined.Results:Mean age was 62.7±15.4 years, and 47.8% (86/180) were male. Among RV measurements, best diagnostic performances were for the smallest 2 annuli for inferior RV (CA1: 0.964, CA2: 0.955). Of the 4 annuli, CA1 had the highest diagnostic performance. Of specific regions, the inferior RV quadrant had the highest performance across CA1 to CA4. Peripapillary RV had similar diagnostic capability compared with RNFL thickness (P>0.05). The artifact rate per B-scan for RV was 6.0%, which was significantly lower compared with 2-dimensional RNFL thickness in the same patient population (32.2%, P<0.0001).Conclusions:The diagnostic capability of RV is similar to RNFL thickness for perimetric open-angle glaucoma, but RV had fewer artifacts compared with RNFL thickness.

KW - open-angle glaucoma

KW - optical coherence tomography

KW - retinal volume

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