Diagnostic capability of three-dimensional macular parameters for glaucoma using optical coherence tomography volume scans

Alice C.Verticchio Vercellin; Firas Jassim; Linda Yi Chieh Poon; Edem Tsikata; Boy Braaf; Sneha Shah; Geulah Ben-David; Eric Shieh; Ramon Lee; Huseyin Simavli; Christian J. Que; Georgia Papadogeorgou; Rong Guo; Benjamin J. Vakoc; Brett E. Bouma; Johannes F. de Boer; Teresa C. Chen

doi:10.1167/iovs.18-23813

Diagnostic capability of three-dimensional macular parameters for glaucoma using optical coherence tomography volume scans

Alice C.Verticchio Vercellin, Firas Jassim, Linda Yi Chieh Poon, Edem Tsikata, Boy Braaf, Sneha Shah, Geulah Ben-David, Eric Shieh, Ramon Lee, Huseyin Simavli, Christian J. Que, Georgia Papadogeorgou, Rong Guo, Benjamin J. Vakoc, Brett E. Bouma, Johannes F. de Boer, Teresa C. Chen^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

PURPOSE. To compare the diagnostic capability of three-dimensional (3D) macular parameters against traditional two-dimensional (2D) retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography. To determine if manual correction and interpolation of B-scans improve the ability of 3D macular parameters to diagnose glaucoma. METHODS. A total of 101 open angle glaucoma patients (29 with early glaucoma) and 57 healthy subjects had peripapillary 2D RNFL thickness and 3D macular volume scans. Four parameters were calculated for six different-sized annuli: total macular thickness (M-thickness), total macular volume (M-volume), ganglion cell complex (GCC) thickness, and GCC volume of the innermost 3 macular layers (retinal nerve fiber layer + ganglion cell layer + inner plexiform layer). All macular parameters were calculated with and without correction and interpolation of frames with artifacts. The areas under the receiver operating characteristic curves (AUROC) were calculated for all the parameters. RESULTS. The 3D macular parameter with the best diagnostic performance was GCC-volume-34, with an inner diameter of 3 mm and an outer of 4 mm. The AUROC for RNFL thickness and GCC-volume-34 were statistically similar for all regions (global: RNFL thickness 0.956, GCC-volume-34 0.939, P value = 0.3827), except for the temporal GCC-volume-34, which was significantly better than temporal RNFL thickness (P value = 0.0067). Correction of artifacts did not significantly change the AUROC of macular parameters (P values between 0.8452 and 1.0000). CONCLUSIONS. The diagnostic performance of best macular parameters (GCC-volume-34 and GCC-thickness-34) were similar to or better than 2D RNFL thickness. Manual correction of artifacts with data interpolation is unnecessary in the clinical setting.

Original language	English
Pages (from-to)	4998-5010
Number of pages	13
Journal	Investigative Ophthalmology and Visual Science
Volume	59
Issue number	12
DOIs	https://doi.org/10.1167/iovs.18-23813
Publication status	Published - 1 Oct 2018

Funding

Supported by the Center for Biomedical OCT Research and Translation through Grant No. P41EB015903 (BB, BJV, BEB), awarded by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (Bethesda, MD, USA); National Institutes of Health UL1 RR 025758; Massachusetts Lions Eye Research Fund (New Bedford, MA, USA); American Glaucoma Society Mid-Career Award (San Francisco, CA, USA); Fidelity Charitable Fund (Harvard University); and Department of Defense Small Business Innovation Research DHP15-016 (TCC).

Funders	Funder number
Fidelity Charitable Fund
National Institutes of Health
U.S. Department of Defense	DHP15-016
National Institute of Biomedical Imaging and Bioengineering
National Center for Research Resources	UL1RR025758
Small Business Innovation Research
Harvard University
Massachusetts Lions Eye Research Fund
American Glaucoma Society

Keywords

Diagnostic capability
Glaucoma
Macula
Spectral domain optical coherence tomography

Access to Document

10.1167/iovs.18-23813

Persistent URL (handle)

Copy link address

Cite this

Vercellin, A. C. V., Jassim, F., Poon, L. Y. C., Tsikata, E., Braaf, B., Shah, S., Ben-David, G., Shieh, E., Lee, R., Simavli, H., Que, C. J., Papadogeorgou, G., Guo, R., Vakoc, B. J., Bouma, B. E., de Boer, J. F., & Chen, T. C. (2018). Diagnostic capability of three-dimensional macular parameters for glaucoma using optical coherence tomography volume scans. Investigative Ophthalmology and Visual Science, 59(12), 4998-5010. https://doi.org/10.1167/iovs.18-23813

@article{13a9b20970b74fafa83a0888c55728c7,

title = "Diagnostic capability of three-dimensional macular parameters for glaucoma using optical coherence tomography volume scans",

abstract = "PURPOSE. To compare the diagnostic capability of three-dimensional (3D) macular parameters against traditional two-dimensional (2D) retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography. To determine if manual correction and interpolation of B-scans improve the ability of 3D macular parameters to diagnose glaucoma. METHODS. A total of 101 open angle glaucoma patients (29 with early glaucoma) and 57 healthy subjects had peripapillary 2D RNFL thickness and 3D macular volume scans. Four parameters were calculated for six different-sized annuli: total macular thickness (M-thickness), total macular volume (M-volume), ganglion cell complex (GCC) thickness, and GCC volume of the innermost 3 macular layers (retinal nerve fiber layer + ganglion cell layer + inner plexiform layer). All macular parameters were calculated with and without correction and interpolation of frames with artifacts. The areas under the receiver operating characteristic curves (AUROC) were calculated for all the parameters. RESULTS. The 3D macular parameter with the best diagnostic performance was GCC-volume-34, with an inner diameter of 3 mm and an outer of 4 mm. The AUROC for RNFL thickness and GCC-volume-34 were statistically similar for all regions (global: RNFL thickness 0.956, GCC-volume-34 0.939, P value = 0.3827), except for the temporal GCC-volume-34, which was significantly better than temporal RNFL thickness (P value = 0.0067). Correction of artifacts did not significantly change the AUROC of macular parameters (P values between 0.8452 and 1.0000). CONCLUSIONS. The diagnostic performance of best macular parameters (GCC-volume-34 and GCC-thickness-34) were similar to or better than 2D RNFL thickness. Manual correction of artifacts with data interpolation is unnecessary in the clinical setting.",

keywords = "Diagnostic capability, Glaucoma, Macula, Spectral domain optical coherence tomography",

author = "Vercellin, {Alice C.Verticchio} and Firas Jassim and Poon, {Linda Yi Chieh} and Edem Tsikata and Boy Braaf and Sneha Shah and Geulah Ben-David and Eric Shieh and Ramon Lee and Huseyin Simavli and Que, {Christian J.} and Georgia Papadogeorgou and Rong Guo and Vakoc, {Benjamin J.} and Bouma, {Brett E.} and {de Boer}, {Johannes F.} and Chen, {Teresa C.}",

year = "2018",

month = oct,

day = "1",

doi = "10.1167/iovs.18-23813",

language = "English",

volume = "59",

pages = "4998--5010",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology",

number = "12",

}

Vercellin, ACV, Jassim, F, Poon, LYC, Tsikata, E, Braaf, B, Shah, S, Ben-David, G, Shieh, E, Lee, R, Simavli, H, Que, CJ, Papadogeorgou, G, Guo, R, Vakoc, BJ, Bouma, BE, de Boer, JF & Chen, TC 2018, 'Diagnostic capability of three-dimensional macular parameters for glaucoma using optical coherence tomography volume scans', Investigative Ophthalmology and Visual Science, vol. 59, no. 12, pp. 4998-5010. https://doi.org/10.1167/iovs.18-23813

Diagnostic capability of three-dimensional macular parameters for glaucoma using optical coherence tomography volume scans. / Vercellin, Alice C.Verticchio; Jassim, Firas; Poon, Linda Yi Chieh et al.
In: Investigative Ophthalmology and Visual Science, Vol. 59, No. 12, 01.10.2018, p. 4998-5010.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Diagnostic capability of three-dimensional macular parameters for glaucoma using optical coherence tomography volume scans

AU - Vercellin, Alice C.Verticchio

AU - Jassim, Firas

AU - Poon, Linda Yi Chieh

AU - Tsikata, Edem

AU - Braaf, Boy

AU - Shah, Sneha

AU - Ben-David, Geulah

AU - Shieh, Eric

AU - Lee, Ramon

AU - Simavli, Huseyin

AU - Que, Christian J.

AU - Papadogeorgou, Georgia

AU - Guo, Rong

AU - Vakoc, Benjamin J.

AU - Bouma, Brett E.

AU - de Boer, Johannes F.

AU - Chen, Teresa C.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - PURPOSE. To compare the diagnostic capability of three-dimensional (3D) macular parameters against traditional two-dimensional (2D) retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography. To determine if manual correction and interpolation of B-scans improve the ability of 3D macular parameters to diagnose glaucoma. METHODS. A total of 101 open angle glaucoma patients (29 with early glaucoma) and 57 healthy subjects had peripapillary 2D RNFL thickness and 3D macular volume scans. Four parameters were calculated for six different-sized annuli: total macular thickness (M-thickness), total macular volume (M-volume), ganglion cell complex (GCC) thickness, and GCC volume of the innermost 3 macular layers (retinal nerve fiber layer + ganglion cell layer + inner plexiform layer). All macular parameters were calculated with and without correction and interpolation of frames with artifacts. The areas under the receiver operating characteristic curves (AUROC) were calculated for all the parameters. RESULTS. The 3D macular parameter with the best diagnostic performance was GCC-volume-34, with an inner diameter of 3 mm and an outer of 4 mm. The AUROC for RNFL thickness and GCC-volume-34 were statistically similar for all regions (global: RNFL thickness 0.956, GCC-volume-34 0.939, P value = 0.3827), except for the temporal GCC-volume-34, which was significantly better than temporal RNFL thickness (P value = 0.0067). Correction of artifacts did not significantly change the AUROC of macular parameters (P values between 0.8452 and 1.0000). CONCLUSIONS. The diagnostic performance of best macular parameters (GCC-volume-34 and GCC-thickness-34) were similar to or better than 2D RNFL thickness. Manual correction of artifacts with data interpolation is unnecessary in the clinical setting.

AB - PURPOSE. To compare the diagnostic capability of three-dimensional (3D) macular parameters against traditional two-dimensional (2D) retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography. To determine if manual correction and interpolation of B-scans improve the ability of 3D macular parameters to diagnose glaucoma. METHODS. A total of 101 open angle glaucoma patients (29 with early glaucoma) and 57 healthy subjects had peripapillary 2D RNFL thickness and 3D macular volume scans. Four parameters were calculated for six different-sized annuli: total macular thickness (M-thickness), total macular volume (M-volume), ganglion cell complex (GCC) thickness, and GCC volume of the innermost 3 macular layers (retinal nerve fiber layer + ganglion cell layer + inner plexiform layer). All macular parameters were calculated with and without correction and interpolation of frames with artifacts. The areas under the receiver operating characteristic curves (AUROC) were calculated for all the parameters. RESULTS. The 3D macular parameter with the best diagnostic performance was GCC-volume-34, with an inner diameter of 3 mm and an outer of 4 mm. The AUROC for RNFL thickness and GCC-volume-34 were statistically similar for all regions (global: RNFL thickness 0.956, GCC-volume-34 0.939, P value = 0.3827), except for the temporal GCC-volume-34, which was significantly better than temporal RNFL thickness (P value = 0.0067). Correction of artifacts did not significantly change the AUROC of macular parameters (P values between 0.8452 and 1.0000). CONCLUSIONS. The diagnostic performance of best macular parameters (GCC-volume-34 and GCC-thickness-34) were similar to or better than 2D RNFL thickness. Manual correction of artifacts with data interpolation is unnecessary in the clinical setting.

KW - Diagnostic capability

KW - Glaucoma

KW - Macula

KW - Spectral domain optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=85055072085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055072085&partnerID=8YFLogxK

U2 - 10.1167/iovs.18-23813

DO - 10.1167/iovs.18-23813

M3 - Article

C2 - 30326067

AN - SCOPUS:85055072085

SN - 0146-0404

VL - 59

SP - 4998

EP - 5010

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 12

ER -

Diagnostic capability of three-dimensional macular parameters for glaucoma using optical coherence tomography volume scans

Abstract

Funding

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this