Diagnostic criteria for sarcopenia relate differently to insulin resistance

A Y Bijlsma, C G M Meskers, D van Heemst, R G J Westendorp, A J M de Craen, A B Maier

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Skeletal muscle is important in insulin-stimulated glucose uptake. Sarcopenia is, therefore, a possible risk factor for insulin resistance. Currently, different diagnostic criteria for sarcopenia include low muscle mass, muscle strength, and walking speed. We assessed these muscle characteristics in relation to insulin resistance in nondiabetics. This cross-sectional study included 301 nondiabetics, mean age 65.9 years. Area under curve (AUC) calculations of insulin and glucose from a 2-h oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) were used as measures of insulin resistance. Muscle characteristics were relative muscle mass (total or appendicular lean mass (ALM) as percentage of body mass), absolute muscle mass (ALM/height(2) and total lean mass), handgrip strength, and walking speed. All muscle characteristics were standardized and analyzed in linear regression models, stratified by gender. For both males and females, relative muscle mass was inversely associated with AUC insulin, AUC glucose, and HOMA-IR (ALM percentage all p ≤ 0.004). Absolute muscle mass was positively associated with AUC insulin and HOMA-IR (ALM/height(2) all p < 0.001) but not with AUC glucose. Adjustments for fat mass attenuated aforementioned associations. There were no associations between handgrip strength and insulin resistance. Walking speed was inversely associated with AUC insulin in males (p = 0.032). The association between muscle characteristics and insulin resistance was strongest for relative muscle mass. Diagnostic criteria for sarcopenia relate differently to insulin resistance. The role of muscle tissue as an internal glucose-regulating organ is better reflected by relative muscle mass than by absolute muscle mass, muscle strength, or walking speed.

Original languageEnglish
Pages (from-to)2367-75
Number of pages9
JournalAge
Volume35
Issue number6
DOIs
Publication statusPublished - Dec 2013

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Sarcopenia
Insulin Resistance
Muscles
Area Under Curve
Insulin
Glucose
Homeostasis
Muscle Strength
Linear Models
Glucose Tolerance Test

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/metabolism
  • Blood Glucose/metabolism
  • Body Composition
  • Diagnosis, Differential
  • Exercise Test
  • Female
  • Follow-Up Studies
  • Glucose Tolerance Test
  • Hand Strength
  • Humans
  • Insulin/blood
  • Insulin Resistance
  • Male
  • Middle Aged
  • Muscle, Skeletal/physiopathology
  • Retrospective Studies
  • Sarcopenia/diagnosis
  • Young Adult

Cite this

Bijlsma, A. Y., Meskers, C. G. M., van Heemst, D., Westendorp, R. G. J., de Craen, A. J. M., & Maier, A. B. (2013). Diagnostic criteria for sarcopenia relate differently to insulin resistance. Age, 35(6), 2367-75. https://doi.org/10.1007/s11357-013-9516-0
Bijlsma, A Y ; Meskers, C G M ; van Heemst, D ; Westendorp, R G J ; de Craen, A J M ; Maier, A B. / Diagnostic criteria for sarcopenia relate differently to insulin resistance. In: Age. 2013 ; Vol. 35, No. 6. pp. 2367-75.
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abstract = "Skeletal muscle is important in insulin-stimulated glucose uptake. Sarcopenia is, therefore, a possible risk factor for insulin resistance. Currently, different diagnostic criteria for sarcopenia include low muscle mass, muscle strength, and walking speed. We assessed these muscle characteristics in relation to insulin resistance in nondiabetics. This cross-sectional study included 301 nondiabetics, mean age 65.9 years. Area under curve (AUC) calculations of insulin and glucose from a 2-h oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) were used as measures of insulin resistance. Muscle characteristics were relative muscle mass (total or appendicular lean mass (ALM) as percentage of body mass), absolute muscle mass (ALM/height(2) and total lean mass), handgrip strength, and walking speed. All muscle characteristics were standardized and analyzed in linear regression models, stratified by gender. For both males and females, relative muscle mass was inversely associated with AUC insulin, AUC glucose, and HOMA-IR (ALM percentage all p ≤ 0.004). Absolute muscle mass was positively associated with AUC insulin and HOMA-IR (ALM/height(2) all p < 0.001) but not with AUC glucose. Adjustments for fat mass attenuated aforementioned associations. There were no associations between handgrip strength and insulin resistance. Walking speed was inversely associated with AUC insulin in males (p = 0.032). The association between muscle characteristics and insulin resistance was strongest for relative muscle mass. Diagnostic criteria for sarcopenia relate differently to insulin resistance. The role of muscle tissue as an internal glucose-regulating organ is better reflected by relative muscle mass than by absolute muscle mass, muscle strength, or walking speed.",
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Bijlsma, AY, Meskers, CGM, van Heemst, D, Westendorp, RGJ, de Craen, AJM & Maier, AB 2013, 'Diagnostic criteria for sarcopenia relate differently to insulin resistance' Age, vol. 35, no. 6, pp. 2367-75. https://doi.org/10.1007/s11357-013-9516-0

Diagnostic criteria for sarcopenia relate differently to insulin resistance. / Bijlsma, A Y; Meskers, C G M; van Heemst, D; Westendorp, R G J; de Craen, A J M; Maier, A B.

In: Age, Vol. 35, No. 6, 12.2013, p. 2367-75.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Diagnostic criteria for sarcopenia relate differently to insulin resistance

AU - Bijlsma, A Y

AU - Meskers, C G M

AU - van Heemst, D

AU - Westendorp, R G J

AU - de Craen, A J M

AU - Maier, A B

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N2 - Skeletal muscle is important in insulin-stimulated glucose uptake. Sarcopenia is, therefore, a possible risk factor for insulin resistance. Currently, different diagnostic criteria for sarcopenia include low muscle mass, muscle strength, and walking speed. We assessed these muscle characteristics in relation to insulin resistance in nondiabetics. This cross-sectional study included 301 nondiabetics, mean age 65.9 years. Area under curve (AUC) calculations of insulin and glucose from a 2-h oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) were used as measures of insulin resistance. Muscle characteristics were relative muscle mass (total or appendicular lean mass (ALM) as percentage of body mass), absolute muscle mass (ALM/height(2) and total lean mass), handgrip strength, and walking speed. All muscle characteristics were standardized and analyzed in linear regression models, stratified by gender. For both males and females, relative muscle mass was inversely associated with AUC insulin, AUC glucose, and HOMA-IR (ALM percentage all p ≤ 0.004). Absolute muscle mass was positively associated with AUC insulin and HOMA-IR (ALM/height(2) all p < 0.001) but not with AUC glucose. Adjustments for fat mass attenuated aforementioned associations. There were no associations between handgrip strength and insulin resistance. Walking speed was inversely associated with AUC insulin in males (p = 0.032). The association between muscle characteristics and insulin resistance was strongest for relative muscle mass. Diagnostic criteria for sarcopenia relate differently to insulin resistance. The role of muscle tissue as an internal glucose-regulating organ is better reflected by relative muscle mass than by absolute muscle mass, muscle strength, or walking speed.

AB - Skeletal muscle is important in insulin-stimulated glucose uptake. Sarcopenia is, therefore, a possible risk factor for insulin resistance. Currently, different diagnostic criteria for sarcopenia include low muscle mass, muscle strength, and walking speed. We assessed these muscle characteristics in relation to insulin resistance in nondiabetics. This cross-sectional study included 301 nondiabetics, mean age 65.9 years. Area under curve (AUC) calculations of insulin and glucose from a 2-h oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) were used as measures of insulin resistance. Muscle characteristics were relative muscle mass (total or appendicular lean mass (ALM) as percentage of body mass), absolute muscle mass (ALM/height(2) and total lean mass), handgrip strength, and walking speed. All muscle characteristics were standardized and analyzed in linear regression models, stratified by gender. For both males and females, relative muscle mass was inversely associated with AUC insulin, AUC glucose, and HOMA-IR (ALM percentage all p ≤ 0.004). Absolute muscle mass was positively associated with AUC insulin and HOMA-IR (ALM/height(2) all p < 0.001) but not with AUC glucose. Adjustments for fat mass attenuated aforementioned associations. There were no associations between handgrip strength and insulin resistance. Walking speed was inversely associated with AUC insulin in males (p = 0.032). The association between muscle characteristics and insulin resistance was strongest for relative muscle mass. Diagnostic criteria for sarcopenia relate differently to insulin resistance. The role of muscle tissue as an internal glucose-regulating organ is better reflected by relative muscle mass than by absolute muscle mass, muscle strength, or walking speed.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging/metabolism

KW - Blood Glucose/metabolism

KW - Body Composition

KW - Diagnosis, Differential

KW - Exercise Test

KW - Female

KW - Follow-Up Studies

KW - Glucose Tolerance Test

KW - Hand Strength

KW - Humans

KW - Insulin/blood

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal/physiopathology

KW - Retrospective Studies

KW - Sarcopenia/diagnosis

KW - Young Adult

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DO - 10.1007/s11357-013-9516-0

M3 - Article

VL - 35

SP - 2367

EP - 2375

JO - Age

JF - Age

SN - 0161-9152

IS - 6

ER -

Bijlsma AY, Meskers CGM, van Heemst D, Westendorp RGJ, de Craen AJM, Maier AB. Diagnostic criteria for sarcopenia relate differently to insulin resistance. Age. 2013 Dec;35(6):2367-75. https://doi.org/10.1007/s11357-013-9516-0