Diagnostic measures for sarcopenia and bone mineral density

A Y Bijlsma, M C G Meskers, M Molendijk, R G J Westendorp, S Sipilä, L Stenroth, E Sillanpää, J S McPhee, D A Jones, M Narici, H Gapeyeva, M Pääsuke, E Seppet, T Voit, Y Barnouin, J Y Hogrel, G Butler-Browne, A B Maier

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

SUMMARY: Currently used diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. These diagnostic measures associate differently to bone mineral density (BMD), as an example of muscle-related clinical outcome. These differences should be taken into account when studying sarcopenia.

INTRODUCTION: Diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. To understand differences between these measures, we determined the association with respect to whole body BMD, as an example of muscle-related clinical outcome.

METHODS: In the European cross-sectional study MYOAGE, 178 young (18-30 years) and 274 healthy old participants (69-81 years) were recruited. Body composition and BMD were evaluated using dual-energy X-ray densitometry. Diagnostic measures for sarcopenia were composed of lean mass as percentage of body mass, appendicular lean mass (ALM) as percentage of body mass, ALM divided by height squared (ALM/height(2)), knee extension torque, grip strength, walking speed, and Timed Up and Go test (TUG). Linear regression models were stratified for sex and age and adjusted for age and country, and body composition in separate models.

RESULTS: Lean mass and ALM/height(2) were positively associated with BMD (P < 0.001). Significance remained in all sex and age subgroups after further adjustment for fat mass, except in old women. Lean mass percentage and ALM percentage were inversely associated with BMD in old women (P < 0.001). These inverse associations disappeared after adjustment for body mass. Knee extension torque and handgrip strength were positively associated with BMD in all subgroups (P < 0.01), except in old women. Walking speed and TUG were not related to BMD.

CONCLUSIONS: The associations between diagnostic measures of sarcopenia and BMD as an example of muscle-related outcome vary widely. Differences between diagnostic measures should be taken into account when studying sarcopenia.

Original languageEnglish
Pages (from-to)2681-91
Number of pages11
JournalOsteoporosis International
Volume24
Issue number10
DOIs
Publication statusPublished - Oct 2013

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Sarcopenia
Bone Density
Muscles
Torque
Muscle Strength
Body Composition
Linear Models
Knee
Photon Absorptiometry
Hand Strength
Healthy Volunteers
Cross-Sectional Studies
Fats

Keywords

  • Absorptiometry, Photon/methods
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Body Composition/physiology
  • Body Weight/physiology
  • Bone Density/physiology
  • Cross-Sectional Studies
  • Exercise Test/methods
  • Female
  • Hand Strength
  • Humans
  • Knee Joint/physiopathology
  • Male
  • Muscle Strength/physiology
  • Muscle, Skeletal/physiopathology
  • Sarcopenia/diagnosis
  • Sex Factors
  • Walking/physiology
  • Young Adult

Cite this

Bijlsma, A. Y., Meskers, M. C. G., Molendijk, M., Westendorp, R. G. J., Sipilä, S., Stenroth, L., ... Maier, A. B. (2013). Diagnostic measures for sarcopenia and bone mineral density. Osteoporosis International, 24(10), 2681-91. https://doi.org/10.1007/s00198-013-2376-8
Bijlsma, A Y ; Meskers, M C G ; Molendijk, M ; Westendorp, R G J ; Sipilä, S ; Stenroth, L ; Sillanpää, E ; McPhee, J S ; Jones, D A ; Narici, M ; Gapeyeva, H ; Pääsuke, M ; Seppet, E ; Voit, T ; Barnouin, Y ; Hogrel, J Y ; Butler-Browne, G ; Maier, A B. / Diagnostic measures for sarcopenia and bone mineral density. In: Osteoporosis International. 2013 ; Vol. 24, No. 10. pp. 2681-91.
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abstract = "SUMMARY: Currently used diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. These diagnostic measures associate differently to bone mineral density (BMD), as an example of muscle-related clinical outcome. These differences should be taken into account when studying sarcopenia.INTRODUCTION: Diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. To understand differences between these measures, we determined the association with respect to whole body BMD, as an example of muscle-related clinical outcome.METHODS: In the European cross-sectional study MYOAGE, 178 young (18-30 years) and 274 healthy old participants (69-81 years) were recruited. Body composition and BMD were evaluated using dual-energy X-ray densitometry. Diagnostic measures for sarcopenia were composed of lean mass as percentage of body mass, appendicular lean mass (ALM) as percentage of body mass, ALM divided by height squared (ALM/height(2)), knee extension torque, grip strength, walking speed, and Timed Up and Go test (TUG). Linear regression models were stratified for sex and age and adjusted for age and country, and body composition in separate models.RESULTS: Lean mass and ALM/height(2) were positively associated with BMD (P < 0.001). Significance remained in all sex and age subgroups after further adjustment for fat mass, except in old women. Lean mass percentage and ALM percentage were inversely associated with BMD in old women (P < 0.001). These inverse associations disappeared after adjustment for body mass. Knee extension torque and handgrip strength were positively associated with BMD in all subgroups (P < 0.01), except in old women. Walking speed and TUG were not related to BMD.CONCLUSIONS: The associations between diagnostic measures of sarcopenia and BMD as an example of muscle-related outcome vary widely. Differences between diagnostic measures should be taken into account when studying sarcopenia.",
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Bijlsma, AY, Meskers, MCG, Molendijk, M, Westendorp, RGJ, Sipilä, S, Stenroth, L, Sillanpää, E, McPhee, JS, Jones, DA, Narici, M, Gapeyeva, H, Pääsuke, M, Seppet, E, Voit, T, Barnouin, Y, Hogrel, JY, Butler-Browne, G & Maier, AB 2013, 'Diagnostic measures for sarcopenia and bone mineral density' Osteoporosis International, vol. 24, no. 10, pp. 2681-91. https://doi.org/10.1007/s00198-013-2376-8

Diagnostic measures for sarcopenia and bone mineral density. / Bijlsma, A Y; Meskers, M C G; Molendijk, M; Westendorp, R G J; Sipilä, S; Stenroth, L; Sillanpää, E; McPhee, J S; Jones, D A; Narici, M; Gapeyeva, H; Pääsuke, M; Seppet, E; Voit, T; Barnouin, Y; Hogrel, J Y; Butler-Browne, G; Maier, A B.

In: Osteoporosis International, Vol. 24, No. 10, 10.2013, p. 2681-91.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Diagnostic measures for sarcopenia and bone mineral density

AU - Bijlsma, A Y

AU - Meskers, M C G

AU - Molendijk, M

AU - Westendorp, R G J

AU - Sipilä, S

AU - Stenroth, L

AU - Sillanpää, E

AU - McPhee, J S

AU - Jones, D A

AU - Narici, M

AU - Gapeyeva, H

AU - Pääsuke, M

AU - Seppet, E

AU - Voit, T

AU - Barnouin, Y

AU - Hogrel, J Y

AU - Butler-Browne, G

AU - Maier, A B

PY - 2013/10

Y1 - 2013/10

N2 - SUMMARY: Currently used diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. These diagnostic measures associate differently to bone mineral density (BMD), as an example of muscle-related clinical outcome. These differences should be taken into account when studying sarcopenia.INTRODUCTION: Diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. To understand differences between these measures, we determined the association with respect to whole body BMD, as an example of muscle-related clinical outcome.METHODS: In the European cross-sectional study MYOAGE, 178 young (18-30 years) and 274 healthy old participants (69-81 years) were recruited. Body composition and BMD were evaluated using dual-energy X-ray densitometry. Diagnostic measures for sarcopenia were composed of lean mass as percentage of body mass, appendicular lean mass (ALM) as percentage of body mass, ALM divided by height squared (ALM/height(2)), knee extension torque, grip strength, walking speed, and Timed Up and Go test (TUG). Linear regression models were stratified for sex and age and adjusted for age and country, and body composition in separate models.RESULTS: Lean mass and ALM/height(2) were positively associated with BMD (P < 0.001). Significance remained in all sex and age subgroups after further adjustment for fat mass, except in old women. Lean mass percentage and ALM percentage were inversely associated with BMD in old women (P < 0.001). These inverse associations disappeared after adjustment for body mass. Knee extension torque and handgrip strength were positively associated with BMD in all subgroups (P < 0.01), except in old women. Walking speed and TUG were not related to BMD.CONCLUSIONS: The associations between diagnostic measures of sarcopenia and BMD as an example of muscle-related outcome vary widely. Differences between diagnostic measures should be taken into account when studying sarcopenia.

AB - SUMMARY: Currently used diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. These diagnostic measures associate differently to bone mineral density (BMD), as an example of muscle-related clinical outcome. These differences should be taken into account when studying sarcopenia.INTRODUCTION: Diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. To understand differences between these measures, we determined the association with respect to whole body BMD, as an example of muscle-related clinical outcome.METHODS: In the European cross-sectional study MYOAGE, 178 young (18-30 years) and 274 healthy old participants (69-81 years) were recruited. Body composition and BMD were evaluated using dual-energy X-ray densitometry. Diagnostic measures for sarcopenia were composed of lean mass as percentage of body mass, appendicular lean mass (ALM) as percentage of body mass, ALM divided by height squared (ALM/height(2)), knee extension torque, grip strength, walking speed, and Timed Up and Go test (TUG). Linear regression models were stratified for sex and age and adjusted for age and country, and body composition in separate models.RESULTS: Lean mass and ALM/height(2) were positively associated with BMD (P < 0.001). Significance remained in all sex and age subgroups after further adjustment for fat mass, except in old women. Lean mass percentage and ALM percentage were inversely associated with BMD in old women (P < 0.001). These inverse associations disappeared after adjustment for body mass. Knee extension torque and handgrip strength were positively associated with BMD in all subgroups (P < 0.01), except in old women. Walking speed and TUG were not related to BMD.CONCLUSIONS: The associations between diagnostic measures of sarcopenia and BMD as an example of muscle-related outcome vary widely. Differences between diagnostic measures should be taken into account when studying sarcopenia.

KW - Absorptiometry, Photon/methods

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Aging/physiology

KW - Body Composition/physiology

KW - Body Weight/physiology

KW - Bone Density/physiology

KW - Cross-Sectional Studies

KW - Exercise Test/methods

KW - Female

KW - Hand Strength

KW - Humans

KW - Knee Joint/physiopathology

KW - Male

KW - Muscle Strength/physiology

KW - Muscle, Skeletal/physiopathology

KW - Sarcopenia/diagnosis

KW - Sex Factors

KW - Walking/physiology

KW - Young Adult

U2 - 10.1007/s00198-013-2376-8

DO - 10.1007/s00198-013-2376-8

M3 - Article

VL - 24

SP - 2681

EP - 2691

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

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Bijlsma AY, Meskers MCG, Molendijk M, Westendorp RGJ, Sipilä S, Stenroth L et al. Diagnostic measures for sarcopenia and bone mineral density. Osteoporosis International. 2013 Oct;24(10):2681-91. https://doi.org/10.1007/s00198-013-2376-8