Diaphragm Muscle Fiber Weakness and Ubiquitin-Proteasome Activation in Critically Ill Patients

P.E. Hooijman, A. Beishuizen, C.C. Witt, M.C. de Waard, A.R.J. Girbes, A.M.E. Spoelstra-de Man, H.W. Niessen, E. Manders, H.W.H. van Hees, C.E. van den Brom, V. Silderhuis, M.W. Lawlor, S. Labeit, G.J.M. Stienen, K.J. Hartemink, M.A. Paul, L.M.A. Heunks, C.A.C. Ottenheijm

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

RATIONALE: The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration of hospital stay. To date, the nature of diaphragm weakness and its underlying pathophysiologic mechanisms are poorly understood.
Original languageEnglish
Pages (from-to)1126-1138
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume191
Issue number10
DOIs
Publication statusPublished - 2015

Fingerprint

Dive into the research topics of 'Diaphragm Muscle Fiber Weakness and Ubiquitin-Proteasome Activation in Critically Ill Patients'. Together they form a unique fingerprint.

Cite this