TY - JOUR
T1 - Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study
AU - Jung, A.Y.
AU - van Duijnhoven, F.J.B.
AU - Nagengast, F.M.
AU - Botma, A.
AU - Heine-Broring, R.C.
AU - Kleibeuker, J.H.
AU - Vasen, H.F.A.
AU - Harryvan, J.L.
AU - Winkels, R.M.
AU - Kampman, E.
PY - 2014
Y1 - 2014
N2 - Purpose: Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high lifetime risk of developing neoplasms. The role of MTHFR C677T genotype in modifying these relationships in LS individuals is also unclear. We investigated associations between dietary intakes of folate, vitamins B2, B6, B12, and methionine and CRT development in a prospective cohort study of 470 mismatch repair gene mutation carriers.
AB - Purpose: Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high lifetime risk of developing neoplasms. The role of MTHFR C677T genotype in modifying these relationships in LS individuals is also unclear. We investigated associations between dietary intakes of folate, vitamins B2, B6, B12, and methionine and CRT development in a prospective cohort study of 470 mismatch repair gene mutation carriers.
U2 - 10.1007/s10552-014-0412-4
DO - 10.1007/s10552-014-0412-4
M3 - Article
SN - 0957-5243
VL - 25
SP - 1119
EP - 1129
JO - CCC. Cancer Causes and Control
JF - CCC. Cancer Causes and Control
IS - 9
ER -
