Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors

M. Blomenrohr, J. Bogerd, R. Leurs, R.W. Schulz, C.P. Tensen, M.A. Zandbergen, H.J. Goos

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Mammalian gonadotropin-releasing hormone receptors (GnRH-Rs) differ from other G protein-coupled receptors in lacking the intracellular C-terminus and in showing an exchange of two otherwise highly conserved Asp (D) and Asn (N) residues in transmembrane domains (TMD) 2 and 7, respectively. However, the first GnRH-R characterized from a nonmammalian vertebrate, the African catfish, does contain an intracellular C-terminus and has D residues in TMD 2 and 7. The functional relevance of these structural features was analysed with D
Original languageEnglish
Pages (from-to)517-522
JournalBiochemical and Biophysical Research Communications
Volume238
DOIs
Publication statusPublished - 1997

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