Abstract
Mammalian gonadotropin-releasing hormone receptors (GnRH-Rs) differ from other G protein-coupled receptors in lacking the intracellular C-terminus and in showing an exchange of two otherwise highly conserved Asp (D) and Asn (N) residues in transmembrane domains (TMD) 2 and 7, respectively. However, the first GnRH-R characterized from a nonmammalian vertebrate, the African catfish, does contain an intracellular C-terminus and has D residues in TMD 2 and 7. The functional relevance of these structural features was analysed with D
Original language | English |
---|---|
Pages (from-to) | 517-522 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 238 |
DOIs | |
Publication status | Published - 1997 |