Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors

M. Blomenrohr; J. Bogerd; R. Leurs; R.W. Schulz; C.P. Tensen; M.A. Zandbergen; H.J. Goos

doi:10.1006/bbrc.1997.7331

Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors

M. Blomenrohr
, J. Bogerd
, R. Leurs
, R.W. Schulz
, C.P. Tensen
, M.A. Zandbergen
, H.J. Goos

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Mammalian gonadotropin-releasing hormone receptors (GnRH-Rs) differ from other G protein-coupled receptors in lacking the intracellular C-terminus and in showing an exchange of two otherwise highly conserved Asp (D) and Asn (N) residues in transmembrane domains (TMD) 2 and 7, respectively. However, the first GnRH-R characterized from a nonmammalian vertebrate, the African catfish, does contain an intracellular C-terminus and has D residues in TMD 2 and 7. The functional relevance of these structural features was analysed with D

Original language	English
Pages (from-to)	517-522
Journal	Biochemical and Biophysical Research Communications
Volume	238
DOIs	https://doi.org/10.1006/bbrc.1997.7331
Publication status	Published - 1997

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10.1006/bbrc.1997.7331

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author = "M. Blomenrohr and J. Bogerd and R. Leurs and R.W. Schulz and C.P. Tensen and M.A. Zandbergen and H.J. Goos",

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T1 - Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors

AU - Blomenrohr, M.

AU - Bogerd, J.

AU - Leurs, R.

AU - Schulz, R.W.

AU - Tensen, C.P.

AU - Zandbergen, M.A.

AU - Goos, H.J.

PY - 1997

Y1 - 1997

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AB - Mammalian gonadotropin-releasing hormone receptors (GnRH-Rs) differ from other G protein-coupled receptors in lacking the intracellular C-terminus and in showing an exchange of two otherwise highly conserved Asp (D) and Asn (N) residues in transmembrane domains (TMD) 2 and 7, respectively. However, the first GnRH-R characterized from a nonmammalian vertebrate, the African catfish, does contain an intracellular C-terminus and has D residues in TMD 2 and 7. The functional relevance of these structural features was analysed with D

U2 - 10.1006/bbrc.1997.7331

DO - 10.1006/bbrc.1997.7331

M3 - Article

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

ER -

Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors

Abstract

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