Differential Effects of Prenatal Testosterone on Lateralization of Handedness and Language

J.M. Lust; R.H. Geuze; C. Beek; P.T. Cohen-Kettenis; A. Bouma; T.G.G. Groothuis

doi:10.1037/a0023293

Differential Effects of Prenatal Testosterone on Lateralization of Handedness and Language

J.M. Lust, R.H. Geuze, C. Beek, P.T. Cohen-Kettenis, A. Bouma, T.G.G. Groothuis

Clinical Child and Family Studies

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective: Handedness is the most noticeable functional expression of cerebral lateralization in humans. However, its developmental process and plasticity remain elusive. It has been postulated that prenatal testosterone (pT) has an effect on human lateralization development. In the present study we examined the relationship between pT and handedness and compared the outcome to previously published data on language lateralization in the same children. Method: pT was assessed from amniotic fluid of healthy pregnant women using radioimmunoassay. Strength and direction of handedness of the children (n = 65 [31 girls, 34 boys], mean age [years]: 6.43, range: 5.97-7.53) was assessed based on hand choice during performance of age appropriate tasks. Regression procedures and the Olkin & Siotani Z-statistic were used. Results: Results demonstrate that higher pT exposure was related to a decrease in strength of handedness (R

Original language	English
Pages (from-to)	581-589
Journal	Neuropsychology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1037/a0023293
Publication status	Published - 2011

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title = "Differential Effects of Prenatal Testosterone on Lateralization of Handedness and Language",

abstract = "Objective: Handedness is the most noticeable functional expression of cerebral lateralization in humans. However, its developmental process and plasticity remain elusive. It has been postulated that prenatal testosterone (pT) has an effect on human lateralization development. In the present study we examined the relationship between pT and handedness and compared the outcome to previously published data on language lateralization in the same children. Method: pT was assessed from amniotic fluid of healthy pregnant women using radioimmunoassay. Strength and direction of handedness of the children (n = 65 [31 girls, 34 boys], mean age [years]: 6.43, range: 5.97-7.53) was assessed based on hand choice during performance of age appropriate tasks. Regression procedures and the Olkin \& Siotani Z-statistic were used. Results: Results demonstrate that higher pT exposure was related to a decrease in strength of handedness (R",

author = "J.M. Lust and R.H. Geuze and C. Beek and P.T. Cohen-Kettenis and A. Bouma and T.G.G. Groothuis",

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T1 - Differential Effects of Prenatal Testosterone on Lateralization of Handedness and Language

AU - Lust, J.M.

AU - Geuze, R.H.

AU - Beek, C.

AU - Cohen-Kettenis, P.T.

AU - Bouma, A.

AU - Groothuis, T.G.G.

PY - 2011

Y1 - 2011

N2 - Objective: Handedness is the most noticeable functional expression of cerebral lateralization in humans. However, its developmental process and plasticity remain elusive. It has been postulated that prenatal testosterone (pT) has an effect on human lateralization development. In the present study we examined the relationship between pT and handedness and compared the outcome to previously published data on language lateralization in the same children. Method: pT was assessed from amniotic fluid of healthy pregnant women using radioimmunoassay. Strength and direction of handedness of the children (n = 65 [31 girls, 34 boys], mean age [years]: 6.43, range: 5.97-7.53) was assessed based on hand choice during performance of age appropriate tasks. Regression procedures and the Olkin & Siotani Z-statistic were used. Results: Results demonstrate that higher pT exposure was related to a decrease in strength of handedness (R

AB - Objective: Handedness is the most noticeable functional expression of cerebral lateralization in humans. However, its developmental process and plasticity remain elusive. It has been postulated that prenatal testosterone (pT) has an effect on human lateralization development. In the present study we examined the relationship between pT and handedness and compared the outcome to previously published data on language lateralization in the same children. Method: pT was assessed from amniotic fluid of healthy pregnant women using radioimmunoassay. Strength and direction of handedness of the children (n = 65 [31 girls, 34 boys], mean age [years]: 6.43, range: 5.97-7.53) was assessed based on hand choice during performance of age appropriate tasks. Regression procedures and the Olkin & Siotani Z-statistic were used. Results: Results demonstrate that higher pT exposure was related to a decrease in strength of handedness (R

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Differential Effects of Prenatal Testosterone on Lateralization of Handedness and Language

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